{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu C"],"funding":["National Institute of General Medical Sciences","NIGMS NIH HHS","Eli Lilly and Company","Novartis"],"pagination":["278-282"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5409222"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(4)"],"pubmed_abstract":["(+)-Ryanodine is a natural product modulator of ryanodine receptors, important intracellular calcium ion channels that play a critical role in signal transduction leading to muscle movement and synaptic transmission. Chemical derivatization of (+)-ryanodine has demonstrated that certain peripheral structural modifications can alter its pharmacology, and that the pyrrole-2-carboxylate ester is critical for high affinity binding to ryanodine receptors. However, the structural variation of available ryanodine analogues has been limited by the challenge of site-specific functionalization of semisynthetic intermediates, such as (+)-ryanodol. Here we report a synthetic strategy that provides access to (+)-ryanodine and the related natural product (+)-20-deoxyspiganthine in 18 and 19 steps, respe"],"journal":["ACS central science"],"pubmed_title":["Chemical Synthesis of (+)-Ryanodine and (+)-20-Deoxyspiganthine."],"pmcid":["PMC5409222"],"funding_grant_id":["RGM097582-01","R35 GM118191-01","R35 GM118191","R01 GM097582","T32 GM007616"],"pubmed_authors":["Han A","Reisman SE","Xu C","Virgil SC"],"additional_accession":[]},"is_claimable":false,"name":"Chemical Synthesis of (+)-Ryanodine and (+)-20-Deoxyspiganthine.","description":"(+)-Ryanodine is a natural product modulator of ryanodine receptors, important intracellular calcium ion channels that play a critical role in signal transduction leading to muscle movement and synaptic transmission. Chemical derivatization of (+)-ryanodine has demonstrated that certain peripheral structural modifications can alter its pharmacology, and that the pyrrole-2-carboxylate ester is critical for high affinity binding to ryanodine receptors. However, the structural variation of available ryanodine analogues has been limited by the challenge of site-specific functionalization of semisynthetic intermediates, such as (+)-ryanodol. Here we report a synthetic strategy that provides access to (+)-ryanodine and the related natural product (+)-20-deoxyspiganthine in 18 and 19 steps, respe","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Apr","modification":"2025-04-05T15:14:02.888Z","creation":"2019-03-27T02:42:17Z"},"accession":"S-EPMC5409222","cross_references":{"pubmed":["28470044"],"doi":["10.1021/acscentsci.6b00361"]}}