biostudies-literatureUnknown7(1)Ji XThe establishment of a collaborative network of transcription factors (TFs) followed by decomposition and then construction of subnetworks is an effective way to obtain sets of collaborative TFs; each set controls a biological process or a complex trait. We previously developed eight gene association methods for genome-wide coexpression analysis between each TF and all other genomic genes and then constructing collaborative networks of TFs but only one algorithm, called Triple-Link Algorithm, for building collaborative subnetworks. In this study, we developed two more algorithms, Single Seed-Growing Algorithm (SSGA) and Multi-Seed Growing Algorithm (MSGA), for building collaborative subnetworks of TFs by identifying the fully-linked triple-node seeds from a decomposed collaborative netwoScientific reports1446https://www.ebi.ac.uk/biostudies/studies/S-EPMC5431152biostudies-literatureSSGA and MSGA: two seed-growing algorithms for constructing collaborative subnetworks.PMC5431152Li JCJi XWei HChen SWei ZDeng WfalseSSGA and MSGA: two seed-growing algorithms for constructing collaborative subnetworks.The establishment of a collaborative network of transcription factors (TFs) followed by decomposition and then construction of subnetworks is an effective way to obtain sets of collaborative TFs; each set controls a biological process or a complex trait. We previously developed eight gene association methods for genome-wide coexpression analysis between each TF and all other genomic genes and then constructing collaborative networks of TFs but only one algorithm, called Triple-Link Algorithm, for building collaborative subnetworks. In this study, we developed two more algorithms, Single Seed-Growing Algorithm (SSGA) and Multi-Seed Growing Algorithm (MSGA), for building collaborative subnetworks of TFs by identifying the fully-linked triple-node seeds from a decomposed collaborative netwo2017-01-01T00:00:00Z2017 May2026-05-04T17:42:09.172Z2019-03-27T02:43:35ZS-EPMC54311522846913810.1038/s41598-017-01556-z