biostudies-literatureDossat AMNHLBI NIH HHSNational Institutes of Health2492-2506https://www.ebi.ac.uk/biostudies/studies/S-EPMC5434648biostudies-literatureUnknown31(6)Cardiovascular dysfunction is highly comorbid with mood disorders, such as anxiety and depression. However, the mechanisms linking cardiovascular dysfunction with the core behavioral features of mood disorder remain poorly understood. In this study, we used mice bearing a knock-in sarcomeric mutation, which is exhibited in human hypertrophic cardiomyopathy (HCM), to investigate the influence of HCM over the development of anxiety and depression. We employed behavioral, MRI, and biochemical techniques in young (3-4 mo) and aged adult (7-8 mo) female mice to examine the effects of HCM on the development of anxiety- and depression-like behaviors. We focused on females because in both humans and rodents, they experience a 2-fold increase in mood disorder prevalence <i>vs.</i> males. Our resultFASEB journal : official publication of the Federation of American Societies for Experimental BiologyPathogenesis of depression- and anxiety-like behavior in an animal model of hypertrophic cardiomyopathy.PMC5434648R01 HL128683R00 HL103840HL128683HL103840K99 HL103840Rosenberg JTFincham FDRuiz ELGrant SCDossat AMSanchez-Gonzalez MAKoutnik APGriffin BKabbaj MLeitner SPinto JRfalsePathogenesis of depression- and anxiety-like behavior in an animal model of hypertrophic cardiomyopathy.Cardiovascular dysfunction is highly comorbid with mood disorders, such as anxiety and depression. However, the mechanisms linking cardiovascular dysfunction with the core behavioral features of mood disorder remain poorly understood. In this study, we used mice bearing a knock-in sarcomeric mutation, which is exhibited in human hypertrophic cardiomyopathy (HCM), to investigate the influence of HCM over the development of anxiety and depression. We employed behavioral, MRI, and biochemical techniques in young (3-4 mo) and aged adult (7-8 mo) female mice to examine the effects of HCM on the development of anxiety- and depression-like behaviors. We focused on females because in both humans and rodents, they experience a 2-fold increase in mood disorder prevalence <i>vs.</i> males. Our result2017-01-01T00:00:00Z2017 Jun2025-04-05T12:00:21.19Z2019-03-26T23:38:41ZS-EPMC54346482823578110.1096/fj.201600955RR10.1096/fj.201600955rr