biostudies-literatureLucas Sandri TBMBF (Bundesministerium für Bildung und Forschung)EDCTP: European and Developing Countries Clinical Trials PartnershipCNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brasil)CAPES (Coordenação de Aperfeiçoamento de Pessoal Superior)e0175973https://www.ebi.ac.uk/biostudies/studies/S-EPMC5435133biostudies-literatureUnknown12(5)<h4>Background</h4>Pathogens exert selective pressure which may lead to substantial changes in host immune responses. The human complement receptor type 1 (CR1) is an innate immune recognition glycoprotein that regulates the activation of the complement pathway and removes opsonized immune complexes. CR1 genetic variants in exon 29 have been associated with expression levels, C1q or C3b binding and increased susceptibility to several infectious diseases. Five distinct CR1 nucleotide substitutions determine the Knops blood group phenotypes, namely Kna/b, McCa/b, Sl1/Sl2, Sl4/Sl5 and KCAM+/-.<h4>Methods</h4>CR1 variants were genotyped by direct sequencing in a cohort of 441 healthy individuals from Brazil, Vietnam, India, Republic of Congo and Ghana.<h4>Results</h4>The distribution of the CRPloS oneGeographical distribution of complement receptor type 1 variants and their associated disease risk.PMC5435133BMBF BRA11/A33; 01DN11001CANTAM (Central Africa Network on Tuberculosis, HIV/AIDs and Malaria)Elumalai PValluri VLThangaraj KTong HVToan NLLucas Sandri TSong LHAdukpo SGiang DPVelavan TPNtoumi FNguetse CNJose de Messias Reason IKremsner PGMeyer CGAntunes Andrade FfalseGeographical distribution of complement receptor type 1 variants and their associated disease risk.<h4>Background</h4>Pathogens exert selective pressure which may lead to substantial changes in host immune responses. The human complement receptor type 1 (CR1) is an innate immune recognition glycoprotein that regulates the activation of the complement pathway and removes opsonized immune complexes. CR1 genetic variants in exon 29 have been associated with expression levels, C1q or C3b binding and increased susceptibility to several infectious diseases. Five distinct CR1 nucleotide substitutions determine the Knops blood group phenotypes, namely Kna/b, McCa/b, Sl1/Sl2, Sl4/Sl5 and KCAM+/-.<h4>Methods</h4>CR1 variants were genotyped by direct sequencing in a cohort of 441 healthy individuals from Brazil, Vietnam, India, Republic of Congo and Ghana.<h4>Results</h4>The distribution of the CR2017-01-01T00:00:00Z20172025-04-19T12:44:16.26Z2019-03-26T22:53:05ZS-EPMC54351332852071510.1371/journal.pone.0175973