{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(19)"],"submitter":["Carvalho RR"],"funding":["NanoNextNL"],"pubmed_abstract":["Plastics, such as cyclic olefin copolymer (COC), are becoming an increasingly popular material for microfluidics. COC is used, in part, because of its (bio)-chemical resistance. However, its inertness and hydrophobicity can be a major downside for many bioapplications. In this paper, we show the first example of a surface-bound selective C-H activation of COC into alcohol C-OH moieties under mild aqueous conditions at room temperature. The nucleophilic COC-OH surface allows for subsequent covalent attachments, such as of a H-terminated silane. The resulting hybrid material (COC-Si-H) was then modified via a photolithographic hydrosilylation in the presence of ω-functionalized 1-alkenes to form a new highly stable, solvent-resistant hybrid surface."],"journal":["ACS applied materials & interfaces"],"pagination":["16644-16650"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5437660"],"repository":["biostudies-literature"],"pubmed_title":["Mild and Selective C-H Activation of COC Microfluidic Channels Allowing Covalent Multifunctional Coatings."],"pmcid":["PMC5437660"],"pubmed_authors":["Zuilhof H","Pujari SP","Vrouwe EX","Carvalho RR"],"additional_accession":[]},"is_claimable":false,"name":"Mild and Selective C-H Activation of COC Microfluidic Channels Allowing Covalent Multifunctional Coatings.","description":"Plastics, such as cyclic olefin copolymer (COC), are becoming an increasingly popular material for microfluidics. COC is used, in part, because of its (bio)-chemical resistance. However, its inertness and hydrophobicity can be a major downside for many bioapplications. In this paper, we show the first example of a surface-bound selective C-H activation of COC into alcohol C-OH moieties under mild aqueous conditions at room temperature. The nucleophilic COC-OH surface allows for subsequent covalent attachments, such as of a H-terminated silane. The resulting hybrid material (COC-Si-H) was then modified via a photolithographic hydrosilylation in the presence of ω-functionalized 1-alkenes to form a new highly stable, solvent-resistant hybrid surface.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 May","modification":"2025-04-19T19:06:32.25Z","creation":"2019-03-27T02:45:26Z"},"accession":"S-EPMC5437660","cross_references":{"pubmed":["28481097"],"doi":["10.1021/acsami.7b02022"]}}