{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(17)"],"submitter":["Du C"],"pubmed_abstract":["Gastric cancer is currently the second leading cause of cancer-related death worldwide, especially in Japan, Korea and China, and the 5-year survival rate of gastric cancer is less than 30%. Thus, it is important to shed more lights on novel agents to prevent gastric cancer or to improve survival rate of the patients. Vitamin D not only maintains calcium and bone homeostasis, but also mostly inhibits tumor genesis, invasion, and metastasis through activation of vitamin D receptor. Although epidemiological results are not consistent, accumulating evidence from gastric cancer cells, animal models, and clinical trials suggest that vitamin D deficiency may increase the risk and mortality of gastric cancer, but vitamin D supplement might be a safe and economical way to prevent or treat gastric "],"journal":["Oncotarget"],"pagination":["29474-29486"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5438745"],"repository":["biostudies-literature"],"pubmed_title":["Pathogenic roles of alterations in vitamin D and vitamin D receptor in gastric tumorigenesis."],"pmcid":["PMC5438745"],"pubmed_authors":["Du C","Dong H","Yang S","Zhao X"],"additional_accession":[]},"is_claimable":false,"name":"Pathogenic roles of alterations in vitamin D and vitamin D receptor in gastric tumorigenesis.","description":"Gastric cancer is currently the second leading cause of cancer-related death worldwide, especially in Japan, Korea and China, and the 5-year survival rate of gastric cancer is less than 30%. Thus, it is important to shed more lights on novel agents to prevent gastric cancer or to improve survival rate of the patients. Vitamin D not only maintains calcium and bone homeostasis, but also mostly inhibits tumor genesis, invasion, and metastasis through activation of vitamin D receptor. Although epidemiological results are not consistent, accumulating evidence from gastric cancer cells, animal models, and clinical trials suggest that vitamin D deficiency may increase the risk and mortality of gastric cancer, but vitamin D supplement might be a safe and economical way to prevent or treat gastric ","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Apr","modification":"2025-04-21T18:47:34.639Z","creation":"2020-11-19T16:52:03Z"},"accession":"S-EPMC5438745","cross_references":{"pubmed":["28206978"],"doi":["10.18632/oncotarget.15298"]}}