biostudies-literatureAlirol ESwiss National Science Foundatione0005612https://www.ebi.ac.uk/biostudies/studies/S-EPMC5446183biostudies-literatureUnknown11(5)<h4>Background</h4>Currently, there is inadequate evidence on which to base clinical management of neurotoxic snakebite envenoming, especially in the choice of initial antivenom dosage. This randomised controlled trial compared the effectiveness and safety of high versus low initial antivenom dosage in victims of neurotoxic envenoming.<h4>Methodology/ principal findings</h4>This was a balanced, randomised, double-blind trial that was conducted in three health care centers located in the Terai plains of Nepal. Participants received either low (two vials) or high (10 vials) initial dosage of Indian polyvalent antivenom. The primary composite outcome consisted of death, the need for assisted ventilation and worsening/recurrence of neurotoxicity. Hourly evaluations followed antivenom treatmentPLoS neglected tropical diseasesDose of antivenom for the treatment of snakebite with neurotoxic envenoming: Evidence from a randomised controlled trial in Nepal.PMC5446183IZ70Z0_131223Paudel VPAdhikary KAlirol ESharma SKGhimire AWarrell DChappuis FTaylor WRPoncet AKuch UCombescure CThapa CfalseDose of antivenom for the treatment of snakebite with neurotoxic envenoming: Evidence from a randomised controlled trial in Nepal.<h4>Background</h4>Currently, there is inadequate evidence on which to base clinical management of neurotoxic snakebite envenoming, especially in the choice of initial antivenom dosage. This randomised controlled trial compared the effectiveness and safety of high versus low initial antivenom dosage in victims of neurotoxic envenoming.<h4>Methodology/ principal findings</h4>This was a balanced, randomised, double-blind trial that was conducted in three health care centers located in the Terai plains of Nepal. Participants received either low (two vials) or high (10 vials) initial dosage of Indian polyvalent antivenom. The primary composite outcome consisted of death, the need for assisted ventilation and worsening/recurrence of neurotoxicity. Hourly evaluations followed antivenom treatment2017-01-01T00:00:00Z2017 May2026-05-04T15:03:38.665Z2019-03-26T22:46:20ZS-EPMC54461832851057410.1371/journal.pntd.0005612