{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Karijolich J"],"funding":["NCI NIH HHS"],"pagination":["6194-6208"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5449642"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["45(10)"],"pubmed_abstract":["Short interspersed nuclear elements (SINEs) are retrotransposons evolutionarily derived from endogenous RNA Polymerase III RNAs. Though SINE elements have undergone exaptation into gene regulatory elements, how transcribed SINE RNA impacts transcriptional and post-transcriptional regulation is largely unknown. This is partly due to a lack of information regarding which of the loci have transcriptional potential. Here, we present an approach (short interspersed nuclear element sequencing, SINE-seq), which selectively profiles RNA Polymerase III-derived SINE RNA, thereby identifying transcriptionally active SINE loci. Applying SINE-seq to monitor murine B2 SINE expression during a gammaherpesvirus infection revealed transcription from 28 270 SINE loci, with ∼50% of active SINE elements resid"],"journal":["Nucleic acids research"],"pubmed_title":["Genome-wide mapping of infection-induced SINE RNAs reveals a role in selective mRNA export."],"pmcid":["PMC5449642"],"funding_grant_id":["R01 CA160556","R01 CA136367"],"pubmed_authors":["Karijolich J","Alla R","Glaunsinger B","Zhao Y"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide mapping of infection-induced SINE RNAs reveals a role in selective mRNA export.","description":"Short interspersed nuclear elements (SINEs) are retrotransposons evolutionarily derived from endogenous RNA Polymerase III RNAs. Though SINE elements have undergone exaptation into gene regulatory elements, how transcribed SINE RNA impacts transcriptional and post-transcriptional regulation is largely unknown. This is partly due to a lack of information regarding which of the loci have transcriptional potential. Here, we present an approach (short interspersed nuclear element sequencing, SINE-seq), which selectively profiles RNA Polymerase III-derived SINE RNA, thereby identifying transcriptionally active SINE loci. Applying SINE-seq to monitor murine B2 SINE expression during a gammaherpesvirus infection revealed transcription from 28 270 SINE loci, with ∼50% of active SINE elements resid","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jun","modification":"2026-04-08T02:02:38.143Z","creation":"2019-03-27T02:46:18Z"},"accession":"S-EPMC5449642","cross_references":{"pubmed":["28334904"],"doi":["10.1093/nar/gkx180"]}}