{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Aldrich MB"],"funding":["Kimberly-Clark Corporation","NHLBI NIH HHS","National Heart, Lung, and Blood Institute","NCI NIH HHS"],"pagination":["116"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5452411"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["<h4>Background</h4>Evidence suggests lymphatic function mediates local rheumatoid arthritis (RA) flares. Yet biologics that target the immune system are dosed systemically via the subcutaneous (SC) administration route, thereby inefficiently reaching local lymphatic compartments. Nanotopography has previously been shown to disrupt tight cellular junctions, potentially enhancing local lymphatic delivery and potentially improving overall therapeutic efficacy.<h4>Method</h4>We first characterized nanotopography (SOFUSA™) delivery of an anti-TNF drug, etanercept, by comparing pharmacokinetic profiles to those obtained by conventional SC, intravenous (IV), and intradermal (ID) routes of administration, and assessed uptake of radiolabeled etanercept in draining lymph nodes (LNs) in single dosing"],"journal":["Arthritis research & therapy"],"pubmed_title":["Lymphatic delivery of etanercept via nanotopography improves response to collagen-induced arthritis."],"pmcid":["PMC5452411"],"funding_grant_id":["R01 HL092923","R01 CA201487"],"pubmed_authors":["Aldrich MB","Rasmussen JC","Sevick-Muraca EM","Velasquez FC","Kwon S","Chan W","Pinkston K","Harvey BR","Ross RF","Azhdarinia A","Fife CE"],"additional_accession":[]},"is_claimable":false,"name":"Lymphatic delivery of etanercept via nanotopography improves response to collagen-induced arthritis.","description":"<h4>Background</h4>Evidence suggests lymphatic function mediates local rheumatoid arthritis (RA) flares. Yet biologics that target the immune system are dosed systemically via the subcutaneous (SC) administration route, thereby inefficiently reaching local lymphatic compartments. Nanotopography has previously been shown to disrupt tight cellular junctions, potentially enhancing local lymphatic delivery and potentially improving overall therapeutic efficacy.<h4>Method</h4>We first characterized nanotopography (SOFUSA™) delivery of an anti-TNF drug, etanercept, by comparing pharmacokinetic profiles to those obtained by conventional SC, intravenous (IV), and intradermal (ID) routes of administration, and assessed uptake of radiolabeled etanercept in draining lymph nodes (LNs) in single dosing","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 May","modification":"2025-04-26T11:07:25.439Z","creation":"2019-03-27T02:46:27Z"},"accession":"S-EPMC5452411","cross_references":{"pubmed":["28566090"],"doi":["10.1186/s13075-017-1323-z"]}}