biostudies-literatureUnknown7(7)Spasojevic MThe synthesis of poly(<i>N</i>-isopropylacrylamide)-b-poly(L-lysine) and poly(<i>N</i>- isopropylacrylamide-co-acrylamide)-b-poly(L-lysine) copolymers was accomplished by combining atom transfer radical polymerization (ATRP) and ring opening polymerization (ROP). For this purpose, a di-functional initiator with protected amino group was successfully synthetized. The ATRP of <i>N</i>-isopropylacrylamide yielded narrowly dispersed polymers with consistent high yields (~80%). Lower yields (~50%) were observed when narrowly dispersed random copolymers of <i>N</i>-isopropylacrylamide and acrylamide where synthesized. Amino-terminated poly(<i>N</i>-isopropylacrylamide) and poly(<i>N</i>-isopropylacrylamide- co-acrylamide) were successfully used as macroinitiators for ROP of <i>N</i>₆-carbobenzoxMaterials (Basel, Switzerland)5305-5326https://www.ebi.ac.uk/biostudies/studies/S-EPMC5455825biostudies-literatureSynthesis and Phase Behavior of Poly(<i>N</i>-isopropylacrylamide)-b- Poly(L-Lysine Hydrochloride) and Poly(<i>N</i>-Isopropylacrylamide- co-Acrylamide)-b-Poly(L-Lysine Hydrochloride).PMC5455825Schouten AJJansen MRPACSSpasojevic Mde Vos PVorenkamp JfalseSynthesis and Phase Behavior of Poly(<i>N</i>-isopropylacrylamide)-b- Poly(L-Lysine Hydrochloride) and Poly(<i>N</i>-Isopropylacrylamide- co-Acrylamide)-b-Poly(L-Lysine Hydrochloride).The synthesis of poly(<i>N</i>-isopropylacrylamide)-b-poly(L-lysine) and poly(<i>N</i>- isopropylacrylamide-co-acrylamide)-b-poly(L-lysine) copolymers was accomplished by combining atom transfer radical polymerization (ATRP) and ring opening polymerization (ROP). For this purpose, a di-functional initiator with protected amino group was successfully synthetized. The ATRP of <i>N</i>-isopropylacrylamide yielded narrowly dispersed polymers with consistent high yields (~80%). Lower yields (~50%) were observed when narrowly dispersed random copolymers of <i>N</i>-isopropylacrylamide and acrylamide where synthesized. Amino-terminated poly(<i>N</i>-isopropylacrylamide) and poly(<i>N</i>-isopropylacrylamide- co-acrylamide) were successfully used as macroinitiators for ROP of <i>N</i>₆-carbobenzox2014-01-01T00:00:00Z2014 Jul2025-04-22T16:41:17.283Z2019-03-27T02:46:38ZS-EPMC54558252878813010.3390/ma7075305