{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jiang X"],"funding":["NIGMS NIH HHS"],"pagination":["975-8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC545855"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["102(4)"],"pubmed_abstract":["This report shows that the direction of polarization of attached mammalian cells determines the direction in which they move. Surfaces micropatterned with appropriately functionalized self-assembled monolayers constrain individual cells to asymmetric geometries (for example, a teardrop); these geometries polarize the morphology of the cell. After electrochemical desorption of the self-assembled monolayers removes these constraints and allows the cells to move across the surface, they move toward their blunt ends."],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Directing cell migration with asymmetric micropatterns."],"pmcid":["PMC545855"],"funding_grant_id":["R01 GM065364","GM 065364"],"pubmed_authors":["Bruzewicz DA","Jiang X","Piel M","Whitesides GM","Wong AP"],"additional_accession":[]},"is_claimable":false,"name":"Directing cell migration with asymmetric micropatterns.","description":"This report shows that the direction of polarization of attached mammalian cells determines the direction in which they move. Surfaces micropatterned with appropriately functionalized self-assembled monolayers constrain individual cells to asymmetric geometries (for example, a teardrop); these geometries polarize the morphology of the cell. After electrochemical desorption of the self-assembled monolayers removes these constraints and allows the cells to move across the surface, they move toward their blunt ends.","dates":{"release":"2005-01-01T00:00:00Z","publication":"2005 Jan","modification":"2025-04-20T01:35:40.035Z","creation":"2019-03-27T01:08:32Z"},"accession":"S-EPMC545855","cross_references":{"pubmed":["15653772"],"doi":["10.1073/pnas.0408954102"]}}