biostudies-literatureJiang XNIGMS NIH HHS975-8https://www.ebi.ac.uk/biostudies/studies/S-EPMC545855biostudies-literatureUnknown102(4)This report shows that the direction of polarization of attached mammalian cells determines the direction in which they move. Surfaces micropatterned with appropriately functionalized self-assembled monolayers constrain individual cells to asymmetric geometries (for example, a teardrop); these geometries polarize the morphology of the cell. After electrochemical desorption of the self-assembled monolayers removes these constraints and allows the cells to move across the surface, they move toward their blunt ends.Proceedings of the National Academy of Sciences of the United States of AmericaDirecting cell migration with asymmetric micropatterns.PMC545855R01 GM065364GM 065364Bruzewicz DAJiang XPiel MWhitesides GMWong APfalseDirecting cell migration with asymmetric micropatterns.This report shows that the direction of polarization of attached mammalian cells determines the direction in which they move. Surfaces micropatterned with appropriately functionalized self-assembled monolayers constrain individual cells to asymmetric geometries (for example, a teardrop); these geometries polarize the morphology of the cell. After electrochemical desorption of the self-assembled monolayers removes these constraints and allows the cells to move across the surface, they move toward their blunt ends.2005-01-01T00:00:00Z2005 Jan2025-04-20T01:35:40.035Z2019-03-27T01:08:32ZS-EPMC5458551565377210.1073/pnas.0408954102