biostudies-literatureUnknown96(22)Zhuo C<h4>Background</h4>Parkinson disease (PD) was considered as the 2nd most prevalent neurodegenerative disorder after Alzheimer disease, while depression is a prevailing nonmotor symptom of PD. Typically used antidepression medication includes tricyclic antidepressants (TCA), selective serotonin reuptake inhibitors (SSRI), serotonin and norepinephrine reuptake inhibitors (SNRI), monoamine-oxidase inhibitors (MAOI), and dopamine agonists (DA). Our study aimed at evaluating the efficacy of antidepressive medications for depression of PD.<h4>Methods</h4>Web of Science, PubMed, Embase, and the Cochrane library were searched for related articles. Traditional meta-analysis and network meta-analysis (NMA) were performed with outcomes including depression score, UPDRS-II, UPDRS-III, and adverse effeMedicinee6698https://www.ebi.ac.uk/biostudies/studies/S-EPMC5459691biostudies-literatureEfficacy of antidepressive medication for depression in Parkinson disease: a network meta-analysis.PMC5459691Xue RJi FTian HLuo LLin XJiang RTao RQu HZhuo CfalseEfficacy of antidepressive medication for depression in Parkinson disease: a network meta-analysis.<h4>Background</h4>Parkinson disease (PD) was considered as the 2nd most prevalent neurodegenerative disorder after Alzheimer disease, while depression is a prevailing nonmotor symptom of PD. Typically used antidepression medication includes tricyclic antidepressants (TCA), selective serotonin reuptake inhibitors (SSRI), serotonin and norepinephrine reuptake inhibitors (SNRI), monoamine-oxidase inhibitors (MAOI), and dopamine agonists (DA). Our study aimed at evaluating the efficacy of antidepressive medications for depression of PD.<h4>Methods</h4>Web of Science, PubMed, Embase, and the Cochrane library were searched for related articles. Traditional meta-analysis and network meta-analysis (NMA) were performed with outcomes including depression score, UPDRS-II, UPDRS-III, and adverse effe2017-01-01T00:00:00Z2017 Jun2025-04-04T12:29:07.075Z2019-03-27T02:46:51ZS-EPMC54596912856252610.1097/MD.0000000000006698