{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hutton ML"],"funding":["Department of Industry, Innovation, Science, Research and Tertiary Education, Australian Government","Faculty of Medicine, Nursing and Health Sciences, Monash University","State Government of Victoria","NHLBI NIH HHS","National Health and Medical Research Council","Wellcome Trust"],"pagination":["219"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5460342"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7"],"pubmed_abstract":["The human pathogen <i>Helicobacter pylori</i> acquires cholesterol from membrane raft domains in eukaryotic cells, commonly known as \"lipid rafts.\" Incorporation of this cholesterol into the <i>H. pylori</i> cell membrane allows the bacterium to avoid clearance by the host immune system and to resist the effects of antibiotics and antimicrobial peptides. The presence of cholesterol in <i>H. pylori</i> bacteria suggested that this pathogen may have cholesterol-enriched domains within its membrane. Consistent with this suggestion, we identified a hypothetical <i>H. pylori</i> protein (HP0248) with homology to the flotillin proteins normally found in the cholesterol-enriched domains of eukaryotic cells. As shown for eukaryotic flotillin proteins, HP0248 was detected in detergent-resistant mem"],"journal":["Frontiers in cellular and infection microbiology"],"pubmed_title":["A <i>Helicobacter pylori</i> Homolog of Eukaryotic Flotillin Is Involved in Cholesterol Accumulation, Epithelial Cell Responses and Host Colonization."],"pmcid":["PMC5460342"],"funding_grant_id":["R01 HL124209","APP1030243","Excellence Award","Operational Infrastructure Support Program to the Hudson Institute of Medical Research","Australian Postgraduate Award","International Postgraduate Scholarship","APP1079904","Graduate Scholarship","Sir Henry Postdoctoral Fellowship","GTN606476"],"pubmed_authors":["Ferrero RL","Kaparakis-Liaskos M","Steer DL","Turner L","Masters SL","Croker BA","D'Costa K","Rossiter AE","Hutton ML","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"A <i>Helicobacter pylori</i> Homolog of Eukaryotic Flotillin Is Involved in Cholesterol Accumulation, Epithelial Cell Responses and Host Colonization.","description":"The human pathogen <i>Helicobacter pylori</i> acquires cholesterol from membrane raft domains in eukaryotic cells, commonly known as \"lipid rafts.\" Incorporation of this cholesterol into the <i>H. pylori</i> cell membrane allows the bacterium to avoid clearance by the host immune system and to resist the effects of antibiotics and antimicrobial peptides. The presence of cholesterol in <i>H. pylori</i> bacteria suggested that this pathogen may have cholesterol-enriched domains within its membrane. Consistent with this suggestion, we identified a hypothetical <i>H. pylori</i> protein (HP0248) with homology to the flotillin proteins normally found in the cholesterol-enriched domains of eukaryotic cells. As shown for eukaryotic flotillin proteins, HP0248 was detected in detergent-resistant mem","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2026-04-15T15:16:41.239Z","creation":"2019-03-27T02:46:58Z"},"accession":"S-EPMC5460342","cross_references":{"pubmed":["28634572"],"doi":["10.3389/fcimb.2017.00219"]}}