{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19(3)"],"submitter":["Tabouret E"],"pubmed_abstract":["<h4>Background</h4>Our aim was to review MRI characteristics of patients with primary CNS lymphoma (PCNSL) enrolled in a randomized phase II trial and to evaluate their potential prognostic value and patterns of relapse, including T2 fluid attenuated inversion recovery (FLAIR) MRI abnormalities.<h4>Methods</h4>Neuroimaging findings in 85 patients with PCNSL enrolled in a prospective trial were reviewed blinded to outcomes. MRI characteristics and responses according to International PCNSL Collaborative Group (IPCG) criteria were correlated with progression-free survival (PFS) and overall survival (OS).<h4>Results</h4>Multivariate analysis showed that objective response at 2 months (P < .001) and at end of treatment (P = .015) were predictors of prolonged OS. Infratentorial location (P = .0"],"journal":["Neuro-oncology"],"pagination":["422-429"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5464299"],"repository":["biostudies-literature"],"pubmed_title":["Patterns of response and relapse in primary CNS lymphomas after first-line chemotherapy: imaging analysis of the ANOCEF-GOELAMS prospective randomized trial."],"pmcid":["PMC5464299"],"pubmed_authors":["Tabouret E","Alentorn A","Larrieu D","Blonski M","Soussain C","Omuro A","Gressin R","Soubeyran P","Houot R","Tanguy ML","Houillier C","Ghesquieres H","Leclercq D","Taillandier L","Martin-Duverneuil N","Gyan E","Choquet S","Hoang-Xuan K","Chinot O"],"additional_accession":[]},"is_claimable":false,"name":"Patterns of response and relapse in primary CNS lymphomas after first-line chemotherapy: imaging analysis of the ANOCEF-GOELAMS prospective randomized trial.","description":"<h4>Background</h4>Our aim was to review MRI characteristics of patients with primary CNS lymphoma (PCNSL) enrolled in a randomized phase II trial and to evaluate their potential prognostic value and patterns of relapse, including T2 fluid attenuated inversion recovery (FLAIR) MRI abnormalities.<h4>Methods</h4>Neuroimaging findings in 85 patients with PCNSL enrolled in a prospective trial were reviewed blinded to outcomes. MRI characteristics and responses according to International PCNSL Collaborative Group (IPCG) criteria were correlated with progression-free survival (PFS) and overall survival (OS).<h4>Results</h4>Multivariate analysis showed that objective response at 2 months (P < .001) and at end of treatment (P = .015) were predictors of prolonged OS. Infratentorial location (P = .0","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Mar","modification":"2026-05-03T19:14:14.746Z","creation":"2025-05-31T23:29:22.997Z"},"accession":"S-EPMC5464299","cross_references":{"pubmed":["27994065"],"doi":["10.1093/neuonc/now238"]}}