biostudies-literatureUnknown19(3)Tabouret E<h4>Background</h4>Our aim was to review MRI characteristics of patients with primary CNS lymphoma (PCNSL) enrolled in a randomized phase II trial and to evaluate their potential prognostic value and patterns of relapse, including T2 fluid attenuated inversion recovery (FLAIR) MRI abnormalities.<h4>Methods</h4>Neuroimaging findings in 85 patients with PCNSL enrolled in a prospective trial were reviewed blinded to outcomes. MRI characteristics and responses according to International PCNSL Collaborative Group (IPCG) criteria were correlated with progression-free survival (PFS) and overall survival (OS).<h4>Results</h4>Multivariate analysis showed that objective response at 2 months (P < .001) and at end of treatment (P = .015) were predictors of prolonged OS. Infratentorial location (P = .0Neuro-oncology422-429https://www.ebi.ac.uk/biostudies/studies/S-EPMC5464299biostudies-literaturePatterns of response and relapse in primary CNS lymphomas after first-line chemotherapy: imaging analysis of the ANOCEF-GOELAMS prospective randomized trial.PMC5464299Tabouret EAlentorn ALarrieu DBlonski MSoussain COmuro AGressin RSoubeyran PHouot RTanguy MLHouillier CGhesquieres HLeclercq DTaillandier LMartin-Duverneuil NGyan EChoquet SHoang-Xuan KChinot OfalsePatterns of response and relapse in primary CNS lymphomas after first-line chemotherapy: imaging analysis of the ANOCEF-GOELAMS prospective randomized trial.<h4>Background</h4>Our aim was to review MRI characteristics of patients with primary CNS lymphoma (PCNSL) enrolled in a randomized phase II trial and to evaluate their potential prognostic value and patterns of relapse, including T2 fluid attenuated inversion recovery (FLAIR) MRI abnormalities.<h4>Methods</h4>Neuroimaging findings in 85 patients with PCNSL enrolled in a prospective trial were reviewed blinded to outcomes. MRI characteristics and responses according to International PCNSL Collaborative Group (IPCG) criteria were correlated with progression-free survival (PFS) and overall survival (OS).<h4>Results</h4>Multivariate analysis showed that objective response at 2 months (P < .001) and at end of treatment (P = .015) were predictors of prolonged OS. Infratentorial location (P = .02017-01-01T00:00:00Z2017 Mar2026-05-03T19:14:14.746Z2025-05-31T23:29:22.997ZS-EPMC54642992799406510.1093/neuonc/now238