biostudies-literatureUnknown19(5)Terrier LM<h4>Background</h4>Anaplastic gangliogliomas (GGGs) are rare tumors whose natural history is poorly documented. We aimed to define their clinical and imaging features and to identify prognostic factors.<h4>Methods</h4>Consecutive cases of anaplastic GGGs in adults prospectively entered into the French Brain Tumor Database between March 2004 and April 2014 were screened. After diagnosis was confirmed by pathological review, clinical, imaging, therapeutic, and outcome data were collected retrospectively.<h4>Results</h4>Forty-three patients with anaplastic GGG (median age, 49.4 y) from 18 centers were included. Presenting symptoms were neurological deficit (37.2%), epileptic seizure (37.2%), or increased intracranial pressure (25.6%). Typical imaging findings were unifocal location (94.7%), cNeuro-oncology678-688https://www.ebi.ac.uk/biostudies/studies/S-EPMC5464461biostudies-literatureNatural course and prognosis of anaplastic gangliogliomas: a multicenter retrospective study of 43 cases from the French Brain Tumor Database.PMC5464461Le Reste PJAubriot-Lorton MHPallud JCaille AMilin SLoiseau HWager MTerrier LMAmelot ABergemer-Fouquet AMFilipiak IVoirin JLubrano VAlmairac FJanot KZanello MFrancois PVelut SMandonnet EUro-Coste EVital ADam Hieu PEmery EMenei PGuyotat JRoche PHRigau VMetellus PFigarella-Branger DRousseau ADebono BZemmoura ILiguoro DClub de Neuro-Oncologie of the Société Française de NeurochirurgieMuckenstrum BGodfraind CIrthum BDelisle MBCzorny AVarlet PBord EZouaoui SCornu PGauchotte GFarah WLot GBauchet LfalseNatural course and prognosis of anaplastic gangliogliomas: a multicenter retrospective study of 43 cases from the French Brain Tumor Database.<h4>Background</h4>Anaplastic gangliogliomas (GGGs) are rare tumors whose natural history is poorly documented. We aimed to define their clinical and imaging features and to identify prognostic factors.<h4>Methods</h4>Consecutive cases of anaplastic GGGs in adults prospectively entered into the French Brain Tumor Database between March 2004 and April 2014 were screened. After diagnosis was confirmed by pathological review, clinical, imaging, therapeutic, and outcome data were collected retrospectively.<h4>Results</h4>Forty-three patients with anaplastic GGG (median age, 49.4 y) from 18 centers were included. Presenting symptoms were neurological deficit (37.2%), epileptic seizure (37.2%), or increased intracranial pressure (25.6%). Typical imaging findings were unifocal location (94.7%), c2017-01-01T00:00:00Z2017 May2025-05-29T20:48:27.04Z2025-05-29T20:48:27.04ZS-EPMC54644612845374710.1093/neuonc/now186