{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Igual Gil C"],"funding":["Deutsche Forschungsgemeinschaft","NIH HHS"],"pagination":["380"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5465262"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8"],"pubmed_abstract":["Aquaporins occupy an essential role in sustaining the salt/water balance in various cells types and tissues. Here, we present new insights into <i>aqp-8</i> expression and regulation in <i>Caenorhabditis elegans</i>. We show, that upon exposure to osmotic stress, <i>aqp-8</i> exhibits a distinct expression pattern within the excretory cell compared to other <i>C. elegans</i> aquaporins expressed. This expression is correlated to the osmolarity of the surrounding medium and can be activated physiologically by osmotic stress or genetically in mutants with constitutively active osmotic stress response. In addition, we found <i>aqp-8</i> expression to be constitutively active in the TRPV channel mutant <i>osm-9(ok1677)</i>. In a genome-wide RNAi screen we identified additional regulators of <i"],"journal":["Frontiers in physiology"],"pubmed_title":["Neuronal Chemosensation and Osmotic Stress Response Converge in the Regulation of <i>aqp-8</i> in <i>C. elegans</i>."],"pmcid":["PMC5465262"],"funding_grant_id":["RO4279/3-1","P40 OD010440"],"pubmed_authors":["Jarius M","von Kries JP","Rohlfing AK","Igual Gil C"],"additional_accession":[]},"is_claimable":false,"name":"Neuronal Chemosensation and Osmotic Stress Response Converge in the Regulation of <i>aqp-8</i> in <i>C. elegans</i>.","description":"Aquaporins occupy an essential role in sustaining the salt/water balance in various cells types and tissues. Here, we present new insights into <i>aqp-8</i> expression and regulation in <i>Caenorhabditis elegans</i>. We show, that upon exposure to osmotic stress, <i>aqp-8</i> exhibits a distinct expression pattern within the excretory cell compared to other <i>C. elegans</i> aquaporins expressed. This expression is correlated to the osmolarity of the surrounding medium and can be activated physiologically by osmotic stress or genetically in mutants with constitutively active osmotic stress response. In addition, we found <i>aqp-8</i> expression to be constitutively active in the TRPV channel mutant <i>osm-9(ok1677)</i>. In a genome-wide RNAi screen we identified additional regulators of <i","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2025-06-01T03:32:23.658Z","creation":"2025-06-01T03:32:23.658Z"},"accession":"S-EPMC5465262","cross_references":{"pubmed":["28649202"],"doi":["10.3389/fphys.2017.00380"]}}