{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(1)"],"submitter":["Song Y"],"pubmed_abstract":["To prepare and evaluate a new radiotracer <sup>18</sup>F-IRS for molecular imaging mutant EGF Receptors in vitro and vivo. Uptake and efflux of <sup>18</sup>F-IRS were performed with four NSCLC cell lines including HCC827, H1975, H358 and H520. In vivo tumor targeting and pharmacokinetics of the radiotracers were also evaluated in HCC827, H1975, H358 and H520 tumor-bearing nude mice by PET/CT imaging. Ex vivo biodistribution assays were performed to quantify the accumulation of <sup>18</sup>F-IRS in vivo. We also performed <sup>18</sup>F-IRS PET/CT imaging of three patients with NSCLC. We labeled this small molecule with QD620 for flow cytometry and confocal imaging analyses. The uptakes of <sup>18</sup>F-IRS by HCC827 and HCC827 tumors were significantly higher than those of H358, H1975 a"],"journal":["Scientific reports"],"pagination":["3121"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5466683"],"repository":["biostudies-literature"],"pubmed_title":["Development and Evaluation of <sup>18</sup>F-IRS for Molecular Imaging Mutant EGF Receptors in NSCLC."],"pmcid":["PMC5466683"],"pubmed_authors":["Xiao Z","Fang F","Wang X","Shen B","Zhang C","Sun X","Wang K","Song Y"],"additional_accession":[]},"is_claimable":false,"name":"Development and Evaluation of <sup>18</sup>F-IRS for Molecular Imaging Mutant EGF Receptors in NSCLC.","description":"To prepare and evaluate a new radiotracer <sup>18</sup>F-IRS for molecular imaging mutant EGF Receptors in vitro and vivo. Uptake and efflux of <sup>18</sup>F-IRS were performed with four NSCLC cell lines including HCC827, H1975, H358 and H520. In vivo tumor targeting and pharmacokinetics of the radiotracers were also evaluated in HCC827, H1975, H358 and H520 tumor-bearing nude mice by PET/CT imaging. Ex vivo biodistribution assays were performed to quantify the accumulation of <sup>18</sup>F-IRS in vivo. We also performed <sup>18</sup>F-IRS PET/CT imaging of three patients with NSCLC. We labeled this small molecule with QD620 for flow cytometry and confocal imaging analyses. The uptakes of <sup>18</sup>F-IRS by HCC827 and HCC827 tumors were significantly higher than those of H358, H1975 a","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jun","modification":"2026-05-03T00:38:21.967Z","creation":"2019-03-27T02:47:19Z"},"accession":"S-EPMC5466683","cross_references":{"pubmed":["28600491"],"doi":["10.1038/s41598-017-01443-7"]}}