{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2017"],"submitter":["Lee WJ"],"funding":["Agency for Science, Technology and Research","Bayard and Virginia Clarkson Endowment"],"pubmed_abstract":["Embryogenesis is an intricate process involving multiple genes and pathways. Some of the key transcription factors controlling specific cell types are the <i>Sox</i> trio, namely, <i>Sox5</i>, <i>Sox6</i>, and <i>Sox9</i>, which play crucial roles in organogenesis working in a concerted manner. Much however still needs to be learned about their combinatorial roles during this process. A developmental genomics and systems biology approach offers to complement the reductionist methodology of current developmental biology and provide a more comprehensive and integrated view of the interrelationships of complex regulatory networks that occur during organogenesis. By combining cell type-specific transcriptome analysis and in vivo ChIP-Seq of the Sox trio using mouse embryos, we provide evidence"],"journal":["BioMed research international"],"pagination":["8932583"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5467288"],"repository":["biostudies-literature"],"pubmed_title":["An Integrative Developmental Genomics and Systems Biology Approach to Identify an In Vivo Sox Trio-Mediated Gene Regulatory Network in Murine Embryos."],"pmcid":["PMC5467288"],"pubmed_authors":["Kraus P","Lim SL","Xing X","Hu X","Lee WJ","Sun W","Sivakamasundari V","Lufkin T","Chatterjee S","Yap SP","Kolatkar PR","Chan HY","Prabhakar S"],"additional_accession":[]},"is_claimable":false,"name":"An Integrative Developmental Genomics and Systems Biology Approach to Identify an In Vivo Sox Trio-Mediated Gene Regulatory Network in Murine Embryos.","description":"Embryogenesis is an intricate process involving multiple genes and pathways. Some of the key transcription factors controlling specific cell types are the <i>Sox</i> trio, namely, <i>Sox5</i>, <i>Sox6</i>, and <i>Sox9</i>, which play crucial roles in organogenesis working in a concerted manner. Much however still needs to be learned about their combinatorial roles during this process. A developmental genomics and systems biology approach offers to complement the reductionist methodology of current developmental biology and provide a more comprehensive and integrated view of the interrelationships of complex regulatory networks that occur during organogenesis. By combining cell type-specific transcriptome analysis and in vivo ChIP-Seq of the Sox trio using mouse embryos, we provide evidence","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2026-05-03T01:09:51.099Z","creation":"2019-03-27T02:47:22Z"},"accession":"S-EPMC5467288","cross_references":{"pubmed":["28630873"],"doi":["10.1155/2017/8932583"]}}