{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2(12)"],"submitter":["Forcade E"],"pubmed_abstract":["Chronic graft-versus-host disease (cGvHD) remains a major complication of allogeneic stem cell transplantation requiring novel therapies. CD146 and CCR5 are expressed by activated T cells and associated with increased T cell migration capacity and Th17 polarization. We performed a multiparametric flow cytometry analysis in a cohort of 40 HSCT patients together with a cGvHD murine model to understand the role of CD146-expressing subsets. We observed an increased frequency of CD146+ CD4 T cells in the 20 patients with active cGvHD with enhanced RORγt expression. This Th17-prone subset was enriched for cells coexpressing CD146 and CCR5 that harbor mixed Th1/Th17 features and were more frequent in cGvHD patients. Utilizing a murine cGvHD model with bronchiolitis obliterans (BO), we observed th"],"journal":["JCI insight"],"pagination":["92111"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5470889"],"repository":["biostudies-literature"],"pubmed_title":["An activated Th17-prone T cell subset involved in chronic graft-versus-host disease sensitive to pharmacological inhibition."],"pmcid":["PMC5470889"],"pubmed_authors":["MacDonald KP","Blanco P","Liu L","Blazar BR","Serody JS","Koreth J","Espada EL","Cutler CS","Flynn R","Soiffer RJ","Hill GR","Chu HW","Paz K","Yang J","Wilkes DS","Gartlan K","Ritz J","Bakoyannis G","Lobera M","Li W","Antin JH","Amet T","Forcade E","Griesenauer B","Jiang D","Du J","Paczesny S"],"additional_accession":[]},"is_claimable":false,"name":"An activated Th17-prone T cell subset involved in chronic graft-versus-host disease sensitive to pharmacological inhibition.","description":"Chronic graft-versus-host disease (cGvHD) remains a major complication of allogeneic stem cell transplantation requiring novel therapies. CD146 and CCR5 are expressed by activated T cells and associated with increased T cell migration capacity and Th17 polarization. We performed a multiparametric flow cytometry analysis in a cohort of 40 HSCT patients together with a cGvHD murine model to understand the role of CD146-expressing subsets. We observed an increased frequency of CD146+ CD4 T cells in the 20 patients with active cGvHD with enhanced RORγt expression. This Th17-prone subset was enriched for cells coexpressing CD146 and CCR5 that harbor mixed Th1/Th17 features and were more frequent in cGvHD patients. Utilizing a murine cGvHD model with bronchiolitis obliterans (BO), we observed th","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jun","modification":"2025-04-19T13:37:16.746Z","creation":"2019-03-27T02:47:38Z"},"accession":"S-EPMC5470889","cross_references":{"pubmed":["28614794"],"doi":["10.1172/jci.insight.92111"]}}