{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ibrahim AS"],"funding":["NIAID NIH HHS"],"pagination":["721-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC547300"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["49(2)"],"pubmed_abstract":["Rhizopus oryzae is the most common cause of zygomycosis, a life-threatening infection that usually occurs in patients with diabetic ketoacidosis. Despite standard therapy, the overall rate of mortality from zygomycosis remains >50%, and new strategies for treatment are urgently needed. The activities of caspofungin acetate (CAS) and other echinocandins (antifungal inhibitors of the synthesis of 1,3-beta-D-glucan synthase [GS]) against the agents of zygomycosis have remained relatively unexplored, especially in animal models of infection. We found that R. oryzae has both an FKS gene, which in other fungi encodes a subunit of the GS synthesis complex, and CAS-susceptible, membrane-associated GS activity. Low-dose but not high-dose CAS improved the survival of mice with diabetic ketoacidosis "],"journal":["Antimicrobial agents and chemotherapy"],"pubmed_title":["Caspofungin inhibits Rhizopus oryzae 1,3-beta-D-glucan synthase, lowers burden in brain measured by quantitative PCR, and improves survival at a low but not a high dose during murine disseminated zygomycosis."],"pmcid":["PMC547300"],"funding_grant_id":["R03 AI054531","R01 AI063503","KO8 AI060641-01","K08 AI060641"],"pubmed_authors":["Spellberg B","Brown K","Ibrahim AS","Douglas CM","Edwards JE","Bowman JC","Avanessian V"],"additional_accession":[]},"is_claimable":false,"name":"Caspofungin inhibits Rhizopus oryzae 1,3-beta-D-glucan synthase, lowers burden in brain measured by quantitative PCR, and improves survival at a low but not a high dose during murine disseminated zygomycosis.","description":"Rhizopus oryzae is the most common cause of zygomycosis, a life-threatening infection that usually occurs in patients with diabetic ketoacidosis. Despite standard therapy, the overall rate of mortality from zygomycosis remains >50%, and new strategies for treatment are urgently needed. The activities of caspofungin acetate (CAS) and other echinocandins (antifungal inhibitors of the synthesis of 1,3-beta-D-glucan synthase [GS]) against the agents of zygomycosis have remained relatively unexplored, especially in animal models of infection. We found that R. oryzae has both an FKS gene, which in other fungi encodes a subunit of the GS synthesis complex, and CAS-susceptible, membrane-associated GS activity. Low-dose but not high-dose CAS improved the survival of mice with diabetic ketoacidosis ","dates":{"release":"2005-01-01T00:00:00Z","publication":"2005 Feb","modification":"2025-04-19T11:30:46.294Z","creation":"2019-03-27T01:08:33Z"},"accession":"S-EPMC547300","cross_references":{"pubmed":["15673756"],"doi":["10.1128/aac.49.2.721-727.2005","10.1128/AAC.49.2.721-727.2005"]}}