{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xiang L"],"funding":["National Natural Science Foundation of China"],"pagination":["6376-6381"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5474811"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["114(24)"],"pubmed_abstract":["MicroRNAs (miRNAs) are known to be essential for retinal maturation and functionality; however, the role of the most abundant miRNAs, the miR-183/96/182 cluster (miR-183 cluster), in photoreceptor cells remains unclear. Here we demonstrate that ablation of two components of the miR-183 cluster, miR-183 and miR-96, significantly affects photoreceptor maturation and maintenance in mice. Morphologically, early-onset dislocated cone nuclei, shortened outer segments and thinned outer nuclear layers are observed in the miR-183/96 double-knockout (DKO) mice. Abnormal photoreceptor responses, including abolished photopic electroretinography (ERG) responses and compromised scotopic ERG responses, reflect the functional changes in the degenerated retina. We further identify Slc6a6 as the cotarget of"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["miR-183/96 plays a pivotal regulatory role in mouse photoreceptor maturation and maintenance."],"pmcid":["PMC5474811"],"funding_grant_id":["81500741","81371059","81522014"],"pubmed_authors":["Cai XB","Wu KC","Zhou GH","Jin ZB","Cheng FF","Sun LF","Xiang L","Zhang CJ","Chen XJ","Lv JN"],"additional_accession":[]},"is_claimable":false,"name":"miR-183/96 plays a pivotal regulatory role in mouse photoreceptor maturation and maintenance.","description":"MicroRNAs (miRNAs) are known to be essential for retinal maturation and functionality; however, the role of the most abundant miRNAs, the miR-183/96/182 cluster (miR-183 cluster), in photoreceptor cells remains unclear. Here we demonstrate that ablation of two components of the miR-183 cluster, miR-183 and miR-96, significantly affects photoreceptor maturation and maintenance in mice. Morphologically, early-onset dislocated cone nuclei, shortened outer segments and thinned outer nuclear layers are observed in the miR-183/96 double-knockout (DKO) mice. Abnormal photoreceptor responses, including abolished photopic electroretinography (ERG) responses and compromised scotopic ERG responses, reflect the functional changes in the degenerated retina. We further identify Slc6a6 as the cotarget of","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jun","modification":"2025-04-04T08:13:17.577Z","creation":"2019-03-27T02:47:55Z"},"accession":"S-EPMC5474811","cross_references":{"pubmed":["28559309"],"doi":["10.1073/pnas.1618757114"]}}