{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Almamun M"],"funding":["Bryan Thomas Campbell Foundation and National Cancer Institute","National Cancer Institute","NCI NIH HHS","National Institutes of Health"],"pagination":["1-12"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5478429"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["58(9)"],"pubmed_abstract":["A complete understanding of the mechanisms involved in the development of pre-B ALL is lacking. In this study, we integrated DNA methylation data and gene expression data to elucidate the impact of aberrant intergenic DNA methylation on gene expression in pre-B ALL. We found a subset of differentially methylated intergenic loci that were associated with altered gene expression in pre-B ALL patients. Notably, 84% of these regions were also bound by transcription factors (TF) known to play roles in differentiation and B-cell development in a lymphoblastoid cell line. Further, an overall downregulation of eRNA transcripts was observed in pre-B ALL patients and these transcripts were associated with the downregulation of putative target genes involved in B-cell migration, proliferation, and ap"],"journal":["Leukemia & lymphoma"],"pubmed_title":["Inferring a role for methylation of intergenic DNA in the regulation of genes aberrantly expressed in precursor B-cell acute lymphoblastic leukemia."],"pmcid":["PMC5478429"],"funding_grant_id":["CA132784","R00 CA132784"],"pubmed_authors":["Kholod O","Johnson NT","Arthur GL","Almamun M","Levinson BT","Stuckel AJ","Davis JW","Taylor KH"],"additional_accession":[]},"is_claimable":false,"name":"Inferring a role for methylation of intergenic DNA in the regulation of genes aberrantly expressed in precursor B-cell acute lymphoblastic leukemia.","description":"A complete understanding of the mechanisms involved in the development of pre-B ALL is lacking. In this study, we integrated DNA methylation data and gene expression data to elucidate the impact of aberrant intergenic DNA methylation on gene expression in pre-B ALL. We found a subset of differentially methylated intergenic loci that were associated with altered gene expression in pre-B ALL patients. Notably, 84% of these regions were also bound by transcription factors (TF) known to play roles in differentiation and B-cell development in a lymphoblastoid cell line. Further, an overall downregulation of eRNA transcripts was observed in pre-B ALL patients and these transcripts were associated with the downregulation of putative target genes involved in B-cell migration, proliferation, and ap","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Sep","modification":"2026-05-03T19:34:58.15Z","creation":"2019-03-26T23:53:47Z"},"accession":"S-EPMC5478429","cross_references":{"pubmed":["28094574"],"doi":["10.1080/10428194.2016.1272683"]}}