{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(1)"],"submitter":["Wakita R"],"pubmed_abstract":["Norepinephrine modulates synaptic plasticity in various brain regions and is implicated in memory formation, consolidation and retrieval. The cerebellum is involved in motor learning, and adaptations of the vestibulo-ocular reflex (VOR) and optokinetic response (OKR) have been studied as models of cerebellum-dependent motor learning. Previous studies showed the involvement of adrenergic systems in the regulation of VOR, OKR and cerebellar synaptic functions. Here, we show differential contributions of β- and α2-adrenergic receptors in the mouse cerebellar flocculus to VOR and OKR control. Effects of application of β- or α2-adrenergic agonist or antagonist into the flocculus suggest that the β-adrenergic receptor activity maintains the VOR gain at high levels and contributes to adaptation o"],"journal":["Scientific reports"],"pagination":["3944"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5479797"],"repository":["biostudies-literature"],"pubmed_title":["Differential regulations of vestibulo-ocular reflex and optokinetic response by β- and α2-adrenergic receptors in the cerebellar flocculus."],"pmcid":["PMC5479797"],"pubmed_authors":["Wakita R","Hirano T","Tabei K","Inoshita T","Funaki A","Tanabe S"],"additional_accession":[]},"is_claimable":false,"name":"Differential regulations of vestibulo-ocular reflex and optokinetic response by β- and α2-adrenergic receptors in the cerebellar flocculus.","description":"Norepinephrine modulates synaptic plasticity in various brain regions and is implicated in memory formation, consolidation and retrieval. The cerebellum is involved in motor learning, and adaptations of the vestibulo-ocular reflex (VOR) and optokinetic response (OKR) have been studied as models of cerebellum-dependent motor learning. Previous studies showed the involvement of adrenergic systems in the regulation of VOR, OKR and cerebellar synaptic functions. Here, we show differential contributions of β- and α2-adrenergic receptors in the mouse cerebellar flocculus to VOR and OKR control. Effects of application of β- or α2-adrenergic agonist or antagonist into the flocculus suggest that the β-adrenergic receptor activity maintains the VOR gain at high levels and contributes to adaptation o","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jun","modification":"2025-04-05T14:22:38.713Z","creation":"2019-03-27T02:48:11Z"},"accession":"S-EPMC5479797","cross_references":{"pubmed":["28638085"],"doi":["10.1038/s41598-017-04273-9"]}}