{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(22)"],"submitter":["Chen XY"],"pubmed_abstract":["Osteoporosis is a disease characterized by structural deterioration of bone tissue, leading to skeletal fragility with increased fracture risk. Calcium phosphates (CaPs) are widely used in bone tissue engineering strategies as they have similarities to bone apatite except for the absence of trace elements (TEs) in the CaPs. Bioactive glasses (BGs) have also been used successfully in clinic for craniomaxillofacial and dental applications during the last two decades due to their excellent potential for bonding with bone and inducing osteoblastic differentiation. In this study, we evaluated the osteogenic effects of the ionic dissolution products of the quaternary Si-Sr-Zn-Mg-codoped CaP (TEs-CaP) or 45S5 Bioglass® (45S5 BG), both as mixtures and separately, on rat bone marrow-derived mesench"],"journal":["Oncotarget"],"pagination":["36578-36590"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5482678"],"repository":["biostudies-literature"],"pubmed_title":["Systematic comparison of biologically active foreign ions-codoped calcium phosphate microparticles on osteogenic differentiation in rat osteoporotic and normal mesenchymal stem cells."],"pmcid":["PMC5482678"],"pubmed_authors":["Zou H","Ma L","Xu SZ","Chen XY","Zhang L","Ting K","Yang GJ","Yang XY","Yang F","Gao CY","Gou ZR","Wang LH","Mou XZ","Wang XW","Zhang XL"],"additional_accession":[]},"is_claimable":false,"name":"Systematic comparison of biologically active foreign ions-codoped calcium phosphate microparticles on osteogenic differentiation in rat osteoporotic and normal mesenchymal stem cells.","description":"Osteoporosis is a disease characterized by structural deterioration of bone tissue, leading to skeletal fragility with increased fracture risk. Calcium phosphates (CaPs) are widely used in bone tissue engineering strategies as they have similarities to bone apatite except for the absence of trace elements (TEs) in the CaPs. Bioactive glasses (BGs) have also been used successfully in clinic for craniomaxillofacial and dental applications during the last two decades due to their excellent potential for bonding with bone and inducing osteoblastic differentiation. In this study, we evaluated the osteogenic effects of the ionic dissolution products of the quaternary Si-Sr-Zn-Mg-codoped CaP (TEs-CaP) or 45S5 Bioglass® (45S5 BG), both as mixtures and separately, on rat bone marrow-derived mesench","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 May","modification":"2026-07-15T23:00:24.605Z","creation":"2019-03-27T02:48:24Z"},"accession":"S-EPMC5482678","cross_references":{"pubmed":["28402265"],"doi":["10.18632/oncotarget.16618"]}}