{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["116(10)"],"submitter":["Wozny AS"],"pubmed_abstract":["<h4>Background</h4>Head and neck squamous cell carcinoma (HNSCC) are resistant to standard treatments, partly due to cancer stem cells (CSCs) localised in hypoxic niches. Compared to X-rays, carbon ion irradiation relies on better ballistic properties, higher relative biological effectiveness and the absence of oxygen effect. Hypoxia-inducible factor-1α (HIF-1α) is involved in the resistance to photons, whereas its role in response to carbon ions remains unclear.<h4>Methods</h4>Two HNSCC cell lines and their CSC sub-population were studied in response to photons or carbon ion irradiation, in normoxia or hypoxia, after inhibition or not of HIF-1α.<h4>Results</h4>Under hypoxia, compared to non-CSCs, HIF-1α is expressed earlier in CSCs. A combined effect photons/hypoxia, less observed with ca"],"journal":["British journal of cancer"],"pagination":["1340-1349"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5482725"],"repository":["biostudies-literature"],"pubmed_title":["Differential pattern of HIF-1α expression in HNSCC cancer stem cells after carbon ion or photon irradiation: one molecular explanation of the oxygen effect."],"pmcid":["PMC5482725"],"pubmed_authors":["Lalle P","Cunha M","Alphonse G","Saintigny Y","Ardail D","Wozny AS","Battiston-Montagne P","Lauret A","Beuve M","Blond E","Magne N","Guy JB","Rodriguez-Lafrasse C"],"additional_accession":[]},"is_claimable":false,"name":"Differential pattern of HIF-1α expression in HNSCC cancer stem cells after carbon ion or photon irradiation: one molecular explanation of the oxygen effect.","description":"<h4>Background</h4>Head and neck squamous cell carcinoma (HNSCC) are resistant to standard treatments, partly due to cancer stem cells (CSCs) localised in hypoxic niches. Compared to X-rays, carbon ion irradiation relies on better ballistic properties, higher relative biological effectiveness and the absence of oxygen effect. Hypoxia-inducible factor-1α (HIF-1α) is involved in the resistance to photons, whereas its role in response to carbon ions remains unclear.<h4>Methods</h4>Two HNSCC cell lines and their CSC sub-population were studied in response to photons or carbon ion irradiation, in normoxia or hypoxia, after inhibition or not of HIF-1α.<h4>Results</h4>Under hypoxia, compared to non-CSCs, HIF-1α is expressed earlier in CSCs. A combined effect photons/hypoxia, less observed with ca","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 May","modification":"2025-06-01T12:11:07.488Z","creation":"2025-06-01T12:11:07.488Z"},"accession":"S-EPMC5482725","cross_references":{"pubmed":["28407653"],"doi":["10.1038/bjc.2017.100"]}}