{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Grygorczuk S"],"funding":["Uniwersytet Medyczny w Bialymstoku"],"pagination":["126"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5483307"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Background
Host factors determining the clinical presentation of tick-borne encephalitis (TBE) are not fully elucidated. The peripheral inflammatory response to TBE virus is hypothesized to facilitate its entry into central nervous system by disrupting the blood-brain barrier with the involvement of a signaling route including Toll-like receptor 3 (TLR3) and pro-inflammatory cytokines macrophage migration inhibitory factor (MIF), tumor necrosis factor-α (TNFα), and interleukin-1 beta (IL-1β).Methods
Concentrations of MIF, TNFα, and IL-1β were measured with commercial ELISA in serum and cerebrospinal fluid (CSF) from 36 hospitalized TBE patients, 7 patients with non-TBE meningitis, and 6 controls. The CSF albumin quotient (AQ) was used as a marker of blood-brain barrier perm"],"journal":["Journal of neuroinflammation"],"pubmed_title":["The increased concentration of macrophage migration inhibitory factor in serum and cerebrospinal fluid of patients with tick-borne encephalitis."],"pmcid":["PMC5483307"],"funding_grant_id":["143-45624L","134-45728L"],"pubmed_authors":["Moniuszko A","Czupryna P","Parczewski M","Swierzbinska R","Dunaj J","Kondrusik M","Grygorczuk S","Pancewicz S"],"additional_accession":[]},"is_claimable":false,"name":"The increased concentration of macrophage migration inhibitory factor in serum and cerebrospinal fluid of patients with tick-borne encephalitis.","description":"Background
Host factors determining the clinical presentation of tick-borne encephalitis (TBE) are not fully elucidated. The peripheral inflammatory response to TBE virus is hypothesized to facilitate its entry into central nervous system by disrupting the blood-brain barrier with the involvement of a signaling route including Toll-like receptor 3 (TLR3) and pro-inflammatory cytokines macrophage migration inhibitory factor (MIF), tumor necrosis factor-α (TNFα), and interleukin-1 beta (IL-1β).Methods
Concentrations of MIF, TNFα, and IL-1β were measured with commercial ELISA in serum and cerebrospinal fluid (CSF) from 36 hospitalized TBE patients, 7 patients with non-TBE meningitis, and 6 controls. The CSF albumin quotient (AQ) was used as a marker of blood-brain barrier perm","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jun","modification":"2025-04-22T11:39:29.682Z","creation":"2019-03-27T02:48:26Z"},"accession":"S-EPMC5483307","cross_references":{"pubmed":["28646884"],"doi":["10.1186/s12974-017-0898-2"]}}