{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fossum S"],"funding":["South-Eastern Norway Regional Health Authority"],"pagination":["1080-1087"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5484313"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["124(7)"],"pubmed_abstract":["<h4>Objective</h4>To investigate whether exposure to hyperemesis gravidarum (HG) is associated with increased maternal long-term mortality.<h4>Design</h4>Population-based cohort study.<h4>Setting</h4>Medical Birth Registry of Norway (1967-2002) linked to the Cause of Death Registry.<h4>Population</h4>Women in Norway with singleton births in the period 1967-2002, with and without HG. Women were followed until 2009 or death.<h4>Methods</h4>Cox proportional hazard regression model was applied to estimate hazard ratios (HRs) with 95% confidence interval (CI).<h4>Main outcome measures</h4>The primary outcome was all-cause mortality during follow up. Secondary outcomes were cause-specific mortality (cardiovascular mortality, deaths due to cancer, external causes or mental and behavioural disorders).<h4>Results</h4>Of 999 161 women with singleton births, 13 397 (1.3%) experienced HG. During a median follow up of 26 years (25 902 036 person-years), 43 470 women died (4.4%). Women exposed to HG had a lower risk of long-term all-cause mortality compared with women without HG (crude HR 0.82; 95% CI 0.75-0.90). When adjusting for confounders, this reduction was no longer significant (adjusted HR 0.92; 95% CI 0.84-1.01). Women exposed to HG had a similar risk of cardiovascular death as women not exposed (adjusted HR 1.04; 95% CI 0.83-1.29), but a lower long-term risk of death from cancer (adjusted HR 0.86; 95% CI 0.75-0.98).<h4>Conclusion</h4>In this large population-based cohort study, HG was not associated with an increased risk of long-term all-cause mortality. Women exposed to HG had no increase in mortality due to cardiovascular disease, but had a reduced risk of death from cancer.<h4>Tweetable abstract</h4>Population-based cohort study: Hyperemesis was not associated with an increased risk of long-term mortality."],"journal":["BJOG : an international journal of obstetrics and gynaecology"],"pubmed_title":["Hyperemesis gravidarum and long-term mortality: a population-based cohort study."],"pmcid":["PMC5484313"],"funding_grant_id":["2015053/2015"],"pubmed_authors":["Naess O","Vikanes AV","Grotmol T","Vos L","Halvorsen S","Fossum S"],"additional_accession":[]},"is_claimable":false,"name":"Hyperemesis gravidarum and long-term mortality: a population-based cohort study.","description":"<h4>Objective</h4>To investigate whether exposure to hyperemesis gravidarum (HG) is associated with increased maternal long-term mortality.<h4>Design</h4>Population-based cohort study.<h4>Setting</h4>Medical Birth Registry of Norway (1967-2002) linked to the Cause of Death Registry.<h4>Population</h4>Women in Norway with singleton births in the period 1967-2002, with and without HG. Women were followed until 2009 or death.<h4>Methods</h4>Cox proportional hazard regression model was applied to estimate hazard ratios (HRs) with 95% confidence interval (CI).<h4>Main outcome measures</h4>The primary outcome was all-cause mortality during follow up. Secondary outcomes were cause-specific mortality (cardiovascular mortality, deaths due to cancer, external causes or mental and behavioural disorders).<h4>Results</h4>Of 999 161 women with singleton births, 13 397 (1.3%) experienced HG. During a median follow up of 26 years (25 902 036 person-years), 43 470 women died (4.4%). Women exposed to HG had a lower risk of long-term all-cause mortality compared with women without HG (crude HR 0.82; 95% CI 0.75-0.90). When adjusting for confounders, this reduction was no longer significant (adjusted HR 0.92; 95% CI 0.84-1.01). Women exposed to HG had a similar risk of cardiovascular death as women not exposed (adjusted HR 1.04; 95% CI 0.83-1.29), but a lower long-term risk of death from cancer (adjusted HR 0.86; 95% CI 0.75-0.98).<h4>Conclusion</h4>In this large population-based cohort study, HG was not associated with an increased risk of long-term all-cause mortality. Women exposed to HG had no increase in mortality due to cardiovascular disease, but had a reduced risk of death from cancer.<h4>Tweetable abstract</h4>Population-based cohort study: Hyperemesis was not associated with an increased risk of long-term mortality.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jun","modification":"2025-04-22T16:44:00.404Z","creation":"2019-03-27T02:48:29Z"},"accession":"S-EPMC5484313","cross_references":{"pubmed":["27981734"],"doi":["10.1111/1471-0528.14454"]}}