biostudies-literatureFossum SSouth-Eastern Norway Regional Health Authority1080-1087https://www.ebi.ac.uk/biostudies/studies/S-EPMC5484313biostudies-literatureUnknown124(7)<h4>Objective</h4>To investigate whether exposure to hyperemesis gravidarum (HG) is associated with increased maternal long-term mortality.<h4>Design</h4>Population-based cohort study.<h4>Setting</h4>Medical Birth Registry of Norway (1967-2002) linked to the Cause of Death Registry.<h4>Population</h4>Women in Norway with singleton births in the period 1967-2002, with and without HG. Women were followed until 2009 or death.<h4>Methods</h4>Cox proportional hazard regression model was applied to estimate hazard ratios (HRs) with 95% confidence interval (CI).<h4>Main outcome measures</h4>The primary outcome was all-cause mortality during follow up. Secondary outcomes were cause-specific mortality (cardiovascular mortality, deaths due to cancer, external causes or mental and behavioural disorders).<h4>Results</h4>Of 999 161 women with singleton births, 13 397 (1.3%) experienced HG. During a median follow up of 26 years (25 902 036 person-years), 43 470 women died (4.4%). Women exposed to HG had a lower risk of long-term all-cause mortality compared with women without HG (crude HR 0.82; 95% CI 0.75-0.90). When adjusting for confounders, this reduction was no longer significant (adjusted HR 0.92; 95% CI 0.84-1.01). Women exposed to HG had a similar risk of cardiovascular death as women not exposed (adjusted HR 1.04; 95% CI 0.83-1.29), but a lower long-term risk of death from cancer (adjusted HR 0.86; 95% CI 0.75-0.98).<h4>Conclusion</h4>In this large population-based cohort study, HG was not associated with an increased risk of long-term all-cause mortality. Women exposed to HG had no increase in mortality due to cardiovascular disease, but had a reduced risk of death from cancer.<h4>Tweetable abstract</h4>Population-based cohort study: Hyperemesis was not associated with an increased risk of long-term mortality.BJOG : an international journal of obstetrics and gynaecologyHyperemesis gravidarum and long-term mortality: a population-based cohort study.PMC54843132015053/2015Naess OVikanes AVGrotmol TVos LHalvorsen SFossum SfalseHyperemesis gravidarum and long-term mortality: a population-based cohort study.<h4>Objective</h4>To investigate whether exposure to hyperemesis gravidarum (HG) is associated with increased maternal long-term mortality.<h4>Design</h4>Population-based cohort study.<h4>Setting</h4>Medical Birth Registry of Norway (1967-2002) linked to the Cause of Death Registry.<h4>Population</h4>Women in Norway with singleton births in the period 1967-2002, with and without HG. Women were followed until 2009 or death.<h4>Methods</h4>Cox proportional hazard regression model was applied to estimate hazard ratios (HRs) with 95% confidence interval (CI).<h4>Main outcome measures</h4>The primary outcome was all-cause mortality during follow up. Secondary outcomes were cause-specific mortality (cardiovascular mortality, deaths due to cancer, external causes or mental and behavioural disorders).<h4>Results</h4>Of 999 161 women with singleton births, 13 397 (1.3%) experienced HG. During a median follow up of 26 years (25 902 036 person-years), 43 470 women died (4.4%). Women exposed to HG had a lower risk of long-term all-cause mortality compared with women without HG (crude HR 0.82; 95% CI 0.75-0.90). When adjusting for confounders, this reduction was no longer significant (adjusted HR 0.92; 95% CI 0.84-1.01). Women exposed to HG had a similar risk of cardiovascular death as women not exposed (adjusted HR 1.04; 95% CI 0.83-1.29), but a lower long-term risk of death from cancer (adjusted HR 0.86; 95% CI 0.75-0.98).<h4>Conclusion</h4>In this large population-based cohort study, HG was not associated with an increased risk of long-term all-cause mortality. Women exposed to HG had no increase in mortality due to cardiovascular disease, but had a reduced risk of death from cancer.<h4>Tweetable abstract</h4>Population-based cohort study: Hyperemesis was not associated with an increased risk of long-term mortality.2017-01-01T00:00:00Z2017 Jun2025-04-22T16:44:00.404Z2019-03-27T02:48:29ZS-EPMC54843132798173410.1111/1471-0528.14454