biostudies-literature00510Das-Munshi JEuropean Research CouncilMedical Research CouncilDepartment of HealthAcademy of Medical Sciences916-924https://www.ebi.ac.uk/biostudies/studies/S-EPMC5484374biostudies-literatureUnknown34(7)<h4>Aims</h4>To investigate whether the association of severe mental illness with Type 2 diabetes varies by ethnicity and age.<h4>Methods</h4>We conducted a cross-sectional analysis of data from an ethnically diverse sample of 588 408 individuals aged ?18 years, registered to 98% of general practices (primary care) in London, UK. The outcome of interest was prevalent Type 2 diabetes.<h4>Results</h4>Relative to people without severe mental illness, the relative risk of Type 2 diabetes in people with severe mental illness was greatest in the youngest age groups. In the white British group the relative risks were 9.99 (95% CI 5.34, 18.69) in those aged 18-34 years, 2.89 (95% CI 2.43, 3.45) in those aged 35-54 years and 1.16 (95% CI 1.04, 1.30) in those aged ?55 years, with similar trends across all ethnic minority groups. Additional adjustment for anti-psychotic prescriptions only marginally attenuated the associations. Assessment of estimated prevalence of Type 2 diabetes in severe mental illness by ethnicity (absolute measures of effect) indicated that the association between severe mental illness and Type 2 diabetes was more marked in ethnic minorities than in the white British group with severe mental illness, especially for Indian, Pakistani and Bangladeshi individuals with severe mental illness.<h4>Conclusions</h4>The relative risk of Type 2 diabetes is elevated in younger populations. Most associations persisted despite adjustment for anti-psychotic prescriptions. Ethnic minority groups had a higher prevalence of Type 2 diabetes in the presence of severe mental illness. Future research and policy, particularly with respect to screening and clinical care for Type 2 diabetes in populations with severe mental illness, should take these findings into account.Diabetic medicine : a journal of the British Diabetic AssociationType 2 diabetes mellitus in people with severe mental illness: inequalities by ethnicity and age. Cross-sectional analysis of 588 408 records from the UK.PMC5484374AMS-CSF4-Das-MunshiNF-SI-0611-10053MR/K021494/1648837Hull SDewey MEDas-Munshi JNazroo JPetersen IThornicroft GSchofield PMorgan CStewart RPrince MJGaughran FAshworth M51falseType 2 diabetes mellitus in people with severe mental illness: inequalities by ethnicity and age. Cross-sectional analysis of 588 408 records from the UK.<h4>Aims</h4>To investigate whether the association of severe mental illness with Type 2 diabetes varies by ethnicity and age.<h4>Methods</h4>We conducted a cross-sectional analysis of data from an ethnically diverse sample of 588 408 individuals aged ?18 years, registered to 98% of general practices (primary care) in London, UK. The outcome of interest was prevalent Type 2 diabetes.<h4>Results</h4>Relative to people without severe mental illness, the relative risk of Type 2 diabetes in people with severe mental illness was greatest in the youngest age groups. In the white British group the relative risks were 9.99 (95% CI 5.34, 18.69) in those aged 18-34 years, 2.89 (95% CI 2.43, 3.45) in those aged 35-54 years and 1.16 (95% CI 1.04, 1.30) in those aged ?55 years, with similar trends across all ethnic minority groups. Additional adjustment for anti-psychotic prescriptions only marginally attenuated the associations. Assessment of estimated prevalence of Type 2 diabetes in severe mental illness by ethnicity (absolute measures of effect) indicated that the association between severe mental illness and Type 2 diabetes was more marked in ethnic minorities than in the white British group with severe mental illness, especially for Indian, Pakistani and Bangladeshi individuals with severe mental illness.<h4>Conclusions</h4>The relative risk of Type 2 diabetes is elevated in younger populations. Most associations persisted despite adjustment for anti-psychotic prescriptions. Ethnic minority groups had a higher prevalence of Type 2 diabetes in the presence of severe mental illness. Future research and policy, particularly with respect to screening and clinical care for Type 2 diabetes in populations with severe mental illness, should take these findings into account.2017-01-01T00:00:00Z2017 Jul2021-02-21T02:24:51Z2019-03-27T02:48:28ZS-EPMC54843742797369210.1111/dme.13298