{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Werth M"],"funding":["Deutsche Forschungsgemeinschaft","NIDDK NIH HHS","March of Dimes Foundation","National Institutes of Health","Urological Research Foundation Berlin"],"pagination":["e24265"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5484618"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6"],"pubmed_abstract":["Although most nephron segments contain one type of epithelial cell, the collecting ducts consists of at least two: intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively. In adult kidneys, these cells are organized in rosettes suggesting functional interactions. Genetic studies in mouse revealed that transcription factor <i>Tfcp2l1</i> coordinates IC and PC development. <i>Tfcp2l1</i> induces the expression of IC specific genes, including specific H<sup>+</sup>-ATPase subunits and <i>Jag1. Jag1</i> in turn, initiates Notch signaling in PCs but inhibits Notch signaling in ICs. <i>Tfcp2l1</i> inactivation deletes ICs, whereas <i>Jag1</i> inactivation results in the forfeiture of discrete IC and PC identities. Thus, <i>Tfcp2l1</i> is a critical regulator of IC-PC patterning, acting cell-autonomously in ICs, and non-cell-autonomously in PCs. As a result, <i>Tfcp2l1</i> regulates the diversification of cell types which is the central characteristic of 'salt and pepper' epithelia and distinguishes the collecting duct from all other nephron segments."],"journal":["eLife"],"pubmed_title":["Transcription factor <i>TFCP2L1</i> patterns cells in the mouse kidney collecting ducts."],"pmcid":["PMC5484618"],"funding_grant_id":["RO1DK073462","FOR1368","U54 DK104309","Research Grant","Emmy Noether","U54DK104309","R01 DK092684","R01 DK073462","P30 DK017047","FOR667","R00 DK094873","RO1DK092684"],"pubmed_authors":["Sarkar A","Lee P","Leete T","Al-Awqati Q","Hinze C","Werth M","Shawber CJ","Barasch J","Lin CS","Qiu A","Rittenberg A","Yu W","Chen X","Mu W","Schmidt-Ott KM","Viltard M","Paragas N","Kitajewski J"],"additional_accession":[]},"is_claimable":false,"name":"Transcription factor <i>TFCP2L1</i> patterns cells in the mouse kidney collecting ducts.","description":"Although most nephron segments contain one type of epithelial cell, the collecting ducts consists of at least two: intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively. In adult kidneys, these cells are organized in rosettes suggesting functional interactions. Genetic studies in mouse revealed that transcription factor <i>Tfcp2l1</i> coordinates IC and PC development. <i>Tfcp2l1</i> induces the expression of IC specific genes, including specific H<sup>+</sup>-ATPase subunits and <i>Jag1. Jag1</i> in turn, initiates Notch signaling in PCs but inhibits Notch signaling in ICs. <i>Tfcp2l1</i> inactivation deletes ICs, whereas <i>Jag1</i> inactivation results in the forfeiture of discrete IC and PC identities. Thus, <i>Tfcp2l1</i> is a critical regulator of IC-PC patterning, acting cell-autonomously in ICs, and non-cell-autonomously in PCs. As a result, <i>Tfcp2l1</i> regulates the diversification of cell types which is the central characteristic of 'salt and pepper' epithelia and distinguishes the collecting duct from all other nephron segments.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jun","modification":"2024-10-18T04:33:40.801Z","creation":"2019-03-27T02:48:30Z"},"accession":"S-EPMC5484618","cross_references":{"pubmed":["28577314"],"doi":["10.7554/eLife.24265"]}}