biostudies-literatureDi Fiore JMNICHD NIH HHSNCATS NIH HHSNCRR NIH HHS49-56.e1https://www.ebi.ac.uk/biostudies/studies/S-EPMC5484739biostudies-literatureUnknown186<h4>Objective</h4>To characterize actual achieved patterns of oxygenation in infants born appropriate vs small for gestational age (SGA) randomized to a lower (85-89%) vs higher (91%-95%) oxygen saturation target in the Surfactant Positive Pressure and Oxygen Trial. To determine the association between achieved oxygen saturation levels and survival in infants born appropriate vs SGA enrolled in the Surfactant Positive Pressure and Oxygen Trial.<h4>Study design</h4>Median oxygen saturation and intermittent hypoxemia events (<80%, 20 seconds-5  minutes) were documented in 1054 infants of 24^0/7-27^6/7 weeks of gestation while receiving supplemental oxygen during the first 3 days of life.<h4>Results</h4>Lower target infants who were small for gestational age had the lowestThe Journal of pediatricsPatterns of Oxygenation, Mortality, and Growth Status in the Surfactant Positive Pressure and Oxygen Trial Cohort.PMC5484739UG1 HD068278U10 HD027904M01 RR000070U10 HD053119UL1 TR001449R03 HD078528UG1 HD034216M01 RR016587UL1 RR025008M01 RR000997UG1 HD027851U10 HD021364UG1 HD027853UG1 HD087226U10 HD040521UG1 HD087229U10 HD040689UG1 HD027856U10 HD053109UG1 HD053089U10 HD027871U10 HD021373UG1 HD021364M01 RR000064UG1 HD027904UL1 TR000454U10 HD040461UL1 RR024979UL1 RR025744UL1 RR024139U10 HD027880U10 HD021385M01 RR007122M01 RR000054UG1 HD040492U10 HD036790U10 HD040498U10 HD040492UG1 HD053109M01 RR000080U10 HD034216U10 HD053124U10 HD027851M01 RR008084U10 HD053089U10 HD027856U10 HD021397M01 RR000044U10 HD027853UG1 HD027880M01 RR006022Foy KASiner BSGrisby CFanaroff AAFiascone JMMacKinnon BLSolis AMcDavid GEPeters NJHerron DEZaterka-Baxter KMMarkowitz GDSchibler KLillie SMartin MHarris BFMartin SDemetrio CJacobs HCAmbalavanan NWatterberg KLCotten CMDuara SIrene ARSood BGMiller LCNylen ETyson JEGoldberg RNBall MBLaroia NO'Shea TMLaptook ARPhelps DLBerberich MAKiley JPTate PLJensen JJNarendran VJohnson KJCrawford MMEhrenkranz RAGuzman AAndrews DWilson LDHale ECBridges KO'Donnell Auman JBhandari VCollins MVJobe AHAngela KBillian EFiner NArnell KTaft JBuchter SPoulsen JCosby SSLacy CBSalhab WACervone PWidness JAZadell ABell EFBarnett SMiller NAPickett JWLepps MHHuitema CPBurnell EHamer FWilder KAllen JCaplan MSGrau LStoll BJCarlton DPKonstantino MWallace DKVasil DMMartin RJProud MSSanchez PJHensley GFisher KAWozniak PRPolin RACarlo WAHensman AMMincey HLLemons JAOsborne KAAuten KJBurnett JHastings BKWright SLGingras DGettner PHessling JLi HLis AEBlaisdell CJVan Meurs KPFurey ARohr JBara RFrancis KSpencer CDi Fiore JMOhls RKFaix RGGail DBWallace DReubens LJShankaran SFreedman SFStevenson DKGantz MGDonovan EFJohnson MHiggins RDRich WWeaver-Lewis KMorris NAlexander BOh WHutchinson AKYoder BABridge REverett-Thomas RArcher SWSUPPORT Study Group of the Eunice Kennedy Shriver National Institute of Child Health, and Human Development Neonatal Research NetworkMersmann MWWalsh MKennedy KANewman NSFrantz IDRasmussen MRKlein JMMorris BHPoindexter BBDas APhillips VAPiazza AJRosenfeld CRfalsePatterns of Oxygenation, Mortality, and Growth Status in the Surfactant Positive Pressure and Oxygen Trial Cohort.<h4>Objective</h4>To characterize actual achieved patterns of oxygenation in infants born appropriate vs small for gestational age (SGA) randomized to a lower (85-89%) vs higher (91%-95%) oxygen saturation target in the Surfactant Positive Pressure and Oxygen Trial. To determine the association between achieved oxygen saturation levels and survival in infants born appropriate vs SGA enrolled in the Surfactant Positive Pressure and Oxygen Trial.<h4>Study design</h4>Median oxygen saturation and intermittent hypoxemia events (<80%, 20 seconds-5  minutes) were documented in 1054 infants of 24^0/7-27^6/7 weeks of gestation while receiving supplemental oxygen during the first 3 days of life.<h4>Results</h4>Lower target infants who were small for gestational age had the lowest2017-01-01T00:00:00Z2017 Jul2025-05-18T12:52:26.973Z2025-05-18T12:52:26.973ZS-EPMC54847392827943310.1016/j.jpeds.2017.01.057