{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18(6)"],"submitter":["Pitrone M"],"pubmed_abstract":["The stromal vascular cell fraction (SVF) of visceral and subcutaneous adipose tissue (VAT and SAT) has increasingly come into focus in stem cell research, since these compartments represent a rich source of multipotent adipose-derived stem cells (ASCs). ASCs exhibit a self-renewal potential and differentiation capacity. Our aim was to study the different expression of the embryonic stem cell markers NANOG (homeobox protein NANOG), SOX2 (SRY (sex determining region Y)-box 2) and OCT4 (octamer-binding transcription factor 4) and to evaluate if there exists a hierarchal role in this network in ASCs derived from both SAT and VAT. ASCs were isolated from SAT and VAT biopsies of 72 consenting patients (23 men, 47 women; age 45 ± 10; BMI between 25 ± 5 and 30 ± 5 range) undergoing elective open-a"],"journal":["International journal of molecular sciences"],"pagination":["E1107"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5485931"],"repository":["biostudies-literature"],"pubmed_title":["NANOG Plays a Hierarchical Role in the Transcription Network Regulating the Pluripotency and Plasticity of Adipose Tissue-Derived Stem Cells."],"pmcid":["PMC5485931"],"pubmed_authors":["Morini L","Perrini S","Giordano C","Pizzolanti G","Pitrone M","Guarnotta V","Tomasello L","Giorgino F","Ficarella R","Coppola A","Pantuso G"],"additional_accession":[]},"is_claimable":false,"name":"NANOG Plays a Hierarchical Role in the Transcription Network Regulating the Pluripotency and Plasticity of Adipose Tissue-Derived Stem Cells.","description":"The stromal vascular cell fraction (SVF) of visceral and subcutaneous adipose tissue (VAT and SAT) has increasingly come into focus in stem cell research, since these compartments represent a rich source of multipotent adipose-derived stem cells (ASCs). ASCs exhibit a self-renewal potential and differentiation capacity. Our aim was to study the different expression of the embryonic stem cell markers NANOG (homeobox protein NANOG), SOX2 (SRY (sex determining region Y)-box 2) and OCT4 (octamer-binding transcription factor 4) and to evaluate if there exists a hierarchal role in this network in ASCs derived from both SAT and VAT. ASCs were isolated from SAT and VAT biopsies of 72 consenting patients (23 men, 47 women; age 45 ± 10; BMI between 25 ± 5 and 30 ± 5 range) undergoing elective open-a","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 May","modification":"2025-05-29T20:49:55.96Z","creation":"2025-05-29T20:49:55.96Z"},"accession":"S-EPMC5485931","cross_references":{"pubmed":["28545230"],"doi":["10.3390/ijms18061107"]}}