{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bousleiman J"],"funding":["NSF","MINECO-FEDER"],"pagination":["E1133"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5485957"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(6)"],"pubmed_abstract":["A study of factors proposed to affect metallothionein-3 (MT3) function was carried out to elucidate the opaque role MT3 plays in human metalloneurochemistry. Gene expression of <i>Mt2</i> and <i>Mt3</i> was examined in tissues extracted from the dentate gyrus of mouse brains and in human neuronal cell cultures. The whole-genome gene expression analysis identified significant variations in the mRNA levels of genes associated with zinc homeostasis, including <i>Mt2</i> and <i>Mt3</i>. <i>Mt3</i> was found to be the most differentially expressed gene in the identified groups, pointing to the existence of a factor, not yet identified, that differentially controls <i>Mt3</i> expression. To examine the expression of the human metallothioneins in neurons, mRNA levels of <i>MT3</i> and <i>MT2</i> "],"journal":["International journal of molecular sciences"],"pubmed_title":["Function of Metallothionein-3 in Neuronal Cells: Do Metal Ions Alter Expression Levels of MT3?"],"pmcid":["PMC5485957"],"funding_grant_id":["CHE-1151957","BIO2015-67358-C2-2-P"],"pubmed_authors":["Austin RN","Ki S","Kalachikov S","Wiqas A","Sever M","Su A","Pinsky A","Silver R","Morozova I","Bousleiman J"],"additional_accession":[]},"is_claimable":false,"name":"Function of Metallothionein-3 in Neuronal Cells: Do Metal Ions Alter Expression Levels of MT3?","description":"A study of factors proposed to affect metallothionein-3 (MT3) function was carried out to elucidate the opaque role MT3 plays in human metalloneurochemistry. Gene expression of <i>Mt2</i> and <i>Mt3</i> was examined in tissues extracted from the dentate gyrus of mouse brains and in human neuronal cell cultures. The whole-genome gene expression analysis identified significant variations in the mRNA levels of genes associated with zinc homeostasis, including <i>Mt2</i> and <i>Mt3</i>. <i>Mt3</i> was found to be the most differentially expressed gene in the identified groups, pointing to the existence of a factor, not yet identified, that differentially controls <i>Mt3</i> expression. To examine the expression of the human metallothioneins in neurons, mRNA levels of <i>MT3</i> and <i>MT2</i> ","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 May","modification":"2026-04-14T09:09:33.219Z","creation":"2019-03-27T02:48:35Z"},"accession":"S-EPMC5485957","cross_references":{"pubmed":["28587098"],"doi":["10.3390/ijms18061133"]}}