{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Arjunan P"],"funding":["NIDCR NIH HHS","National Institutes of Health/NIDCR"],"pagination":["78-93"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5486950"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(1)"],"pubmed_abstract":["The human microbiome consists of highly diverse microbial communities that colonize our skin and mucosal surfaces, aiding in maintenance of immune homeostasis. The keystone pathogen Porphyromonas gingivalis induces a dysbiosis and disrupts immune homeostasis through as yet unclear mechanisms. The fimbrial adhesins of P. gingivalis facilitate biofilm formation, invasion of and dissemination by blood dendritic cells; hence, fimbriae may be key factors in disruption of immune homeostasis. In this study we employed RNA-sequencing transcriptome profiling to identify differentially expressed genes (DEGs) in human monocyte-derived dendritic cells (MoDCs) in response to in vitro infection/exposure by Pg381 or its isogenic mutant strains that solely express minor-Mfa1 fimbriae (DPG3), major-FimA fi"],"journal":["Molecular oral microbiology"],"pubmed_title":["High-throughput sequencing reveals key genes and immune homeostatic pathways activated in myeloid dendritic cells by Porphyromonas gingivalis 381 and its fimbrial mutants."],"pmcid":["PMC5486950"],"funding_grant_id":["R01 DE014328","R01 DE14328-09","RO1 DE14328-09","R21 DE020916","F31 DE020014"],"pubmed_authors":["El-Awady A","Kunde-Ramamoorthy G","Arjunan P","Cutler CW","Dannebaum RO"],"additional_accession":[]},"is_claimable":false,"name":"High-throughput sequencing reveals key genes and immune homeostatic pathways activated in myeloid dendritic cells by Porphyromonas gingivalis 381 and its fimbrial mutants.","description":"The human microbiome consists of highly diverse microbial communities that colonize our skin and mucosal surfaces, aiding in maintenance of immune homeostasis. The keystone pathogen Porphyromonas gingivalis induces a dysbiosis and disrupts immune homeostasis through as yet unclear mechanisms. The fimbrial adhesins of P. gingivalis facilitate biofilm formation, invasion of and dissemination by blood dendritic cells; hence, fimbriae may be key factors in disruption of immune homeostasis. In this study we employed RNA-sequencing transcriptome profiling to identify differentially expressed genes (DEGs) in human monocyte-derived dendritic cells (MoDCs) in response to in vitro infection/exposure by Pg381 or its isogenic mutant strains that solely express minor-Mfa1 fimbriae (DPG3), major-FimA fi","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Feb","modification":"2026-04-14T09:20:08.722Z","creation":"2019-03-27T02:48:38Z"},"accession":"S-EPMC5486950","cross_references":{"pubmed":["26466817"],"doi":["10.1111/omi.12131"]}}