{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Toma W"],"funding":["VCU Massey Cancer Center","NCI NIH HHS","NIH-NCI Cancer Center","NIH"],"pagination":["305-315"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5489229"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["117"],"pubmed_abstract":["Paclitaxel, one of the most commonly used cancer chemotherapeutic drugs, effectively extends the progression-free survival of breast, lung, and ovarian cancer patients. However, paclitaxel and other chemotherapy drugs elicit peripheral nerve fiber dysfunction or degeneration that leads to peripheral neuropathy in a large proportion of cancer patients. Patients receiving chemotherapy also often experience changes in mood, including anxiety and depression. These somatic and affective disorders represent major dose-limiting side effects of chemotherapy. Consequently, the present study was designed to develop a preclinical model of paclitaxel-induced negative affective symptoms in order to identify treatment strategies and their underlying mechanisms of action. Intraperitoneal injections of pa"],"journal":["Neuropharmacology"],"pubmed_title":["Effects of paclitaxel on the development of neuropathy and affective behaviors in the mouse."],"pmcid":["PMC5489229"],"funding_grant_id":["R01 CA206028","R01-CA206028","P30 CA016059"],"pubmed_authors":["Toma W","Bigbee JW","Kyte SL","Damaj MI","Chen ZJ","Del Fabbro E","Alsharari SD","Lichtman AH","Bagdas D","Alkhlaif Y","Gewirtz DA"],"additional_accession":[]},"is_claimable":false,"name":"Effects of paclitaxel on the development of neuropathy and affective behaviors in the mouse.","description":"Paclitaxel, one of the most commonly used cancer chemotherapeutic drugs, effectively extends the progression-free survival of breast, lung, and ovarian cancer patients. However, paclitaxel and other chemotherapy drugs elicit peripheral nerve fiber dysfunction or degeneration that leads to peripheral neuropathy in a large proportion of cancer patients. Patients receiving chemotherapy also often experience changes in mood, including anxiety and depression. These somatic and affective disorders represent major dose-limiting side effects of chemotherapy. Consequently, the present study was designed to develop a preclinical model of paclitaxel-induced negative affective symptoms in order to identify treatment strategies and their underlying mechanisms of action. Intraperitoneal injections of pa","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 May","modification":"2025-08-13T03:06:20.268Z","creation":"2025-08-13T03:06:20.268Z"},"accession":"S-EPMC5489229","cross_references":{"pubmed":["28237807"],"doi":["10.1016/j.neuropharm.2017.02.020"]}}