{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["91(7)"],"submitter":["Pickup K"],"pubmed_abstract":["The distribution, metabolism, excretion and hepatic effects of the human hepatotoxin fenclozic acid were investigated following single oral doses of 10 mg/kg to normal and bile duct-cannulated male C57BL/6J mice. Whole body autoradiography showed distribution into all tissues except the brain, with radioactivity still detectable in blood, kidney and liver at 72 h post-dose. Mice dosed with [<sup>14</sup>C]-fenclozic acid showed acute centrilobular hepatocellular necrosis, but no other regions of the liver were affected. The majority of the [<sup>14</sup>C]-fenclozic acid-related material recovered was found in the urine/aqueous cage wash, (49%) whilst a smaller portion (13%) was eliminated via the faeces. Metabolic profiles for urine, bile and faecal extracts, obtained using liquid chromat"],"journal":["Archives of toxicology"],"pagination":["2643-2653"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5489613"],"repository":["biostudies-literature"],"pubmed_title":["Acute liver effects, disposition and metabolic fate of [<sup>14</sup>C]-fenclozic acid following oral administration to normal and bile-cannulated male C57BL/6J mice."],"pmcid":["PMC5489613"],"pubmed_authors":["Partridge EA","Jones HB","Pickup K","Ratcliffe K","Wills J","Sarda S","Rodrigues A","Page C","Wilson ID","Martin S","Schulz-Utermoehl T","McCarthy A"],"additional_accession":[]},"is_claimable":false,"name":"Acute liver effects, disposition and metabolic fate of [<sup>14</sup>C]-fenclozic acid following oral administration to normal and bile-cannulated male C57BL/6J mice.","description":"The distribution, metabolism, excretion and hepatic effects of the human hepatotoxin fenclozic acid were investigated following single oral doses of 10 mg/kg to normal and bile duct-cannulated male C57BL/6J mice. Whole body autoradiography showed distribution into all tissues except the brain, with radioactivity still detectable in blood, kidney and liver at 72 h post-dose. Mice dosed with [<sup>14</sup>C]-fenclozic acid showed acute centrilobular hepatocellular necrosis, but no other regions of the liver were affected. The majority of the [<sup>14</sup>C]-fenclozic acid-related material recovered was found in the urine/aqueous cage wash, (49%) whilst a smaller portion (13%) was eliminated via the faeces. Metabolic profiles for urine, bile and faecal extracts, obtained using liquid chromat","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jul","modification":"2025-04-04T12:29:32.163Z","creation":"2019-03-27T02:48:49Z"},"accession":"S-EPMC5489613","cross_references":{"pubmed":["27896398"],"doi":["10.1007/s00204-016-1894-5"]}}