biostudies-literatureUnknown91(7)Pickup KThe distribution, metabolism, excretion and hepatic effects of the human hepatotoxin fenclozic acid were investigated following single oral doses of 10 mg/kg to normal and bile duct-cannulated male C57BL/6J mice. Whole body autoradiography showed distribution into all tissues except the brain, with radioactivity still detectable in blood, kidney and liver at 72 h post-dose. Mice dosed with [¹⁴C]-fenclozic acid showed acute centrilobular hepatocellular necrosis, but no other regions of the liver were affected. The majority of the [¹⁴C]-fenclozic acid-related material recovered was found in the urine/aqueous cage wash, (49%) whilst a smaller portion (13%) was eliminated via the faeces. Metabolic profiles for urine, bile and faecal extracts, obtained using liquid chromatArchives of toxicology2643-2653https://www.ebi.ac.uk/biostudies/studies/S-EPMC5489613biostudies-literatureAcute liver effects, disposition and metabolic fate of [¹⁴C]-fenclozic acid following oral administration to normal and bile-cannulated male C57BL/6J mice.PMC5489613Partridge EAJones HBPickup KRatcliffe KWills JSarda SRodrigues APage CWilson IDMartin SSchulz-Utermoehl TMcCarthy AfalseAcute liver effects, disposition and metabolic fate of [¹⁴C]-fenclozic acid following oral administration to normal and bile-cannulated male C57BL/6J mice.The distribution, metabolism, excretion and hepatic effects of the human hepatotoxin fenclozic acid were investigated following single oral doses of 10 mg/kg to normal and bile duct-cannulated male C57BL/6J mice. Whole body autoradiography showed distribution into all tissues except the brain, with radioactivity still detectable in blood, kidney and liver at 72 h post-dose. Mice dosed with [¹⁴C]-fenclozic acid showed acute centrilobular hepatocellular necrosis, but no other regions of the liver were affected. The majority of the [¹⁴C]-fenclozic acid-related material recovered was found in the urine/aqueous cage wash, (49%) whilst a smaller portion (13%) was eliminated via the faeces. Metabolic profiles for urine, bile and faecal extracts, obtained using liquid chromat2017-01-01T00:00:00Z2017 Jul2025-04-04T12:29:32.163Z2019-03-27T02:48:49ZS-EPMC54896132789639810.1007/s00204-016-1894-5