biostudies-literatureXu LKey Project of the Chinese National Program for Fundamental Research and DevelopmentChinese Academy of Medical Sciences Innovation Fund for Medical SciencesNational Natural Scientific FoundationXiehe Scholar Funde3405https://www.ebi.ac.uk/biostudies/studies/S-EPMC5490461biostudies-literatureUnknown5<h4>Aim</h4>To evaluate the effects of sodium-glucose co-transporter 2 (SGLT2) inhibition on renal function and albuminuria in patients with type 2 diabetes.<h4>Methods</h4>We conducted systematic searches of PubMed, Embase and Cochrane Central Register of Controlled Trials up to June 2016 and included randomized controlled trials of SGLT2 inhibitors in adult type 2 diabetic patients reporting estimated glomerular filtration rate (eGFR) and/or urine albumin/creatinine ratio (ACR) changes. Data were synthesized using the random-effects model.<h4>Results</h4>Forty-seven studies with 22,843 participants were included. SGLT2 inhibition was not associated with a significant change in eGFR in general (weighted mean difference (WMD), -0.33 ml/min per 1.73 m², 95% CI [-0.90 to 0.23]) orPeerJEffects of sodium-glucose co-transporter 2 (SGLT2) inhibition on renal function and albuminuria in patients with type 2 diabetes: a systematic review and meta-analysis.PMC54904612016-I2M-2-004814709372012CB51780381170674Xu LLi YLang JChen LXia PZhao XWang LYu YfalseEffects of sodium-glucose co-transporter 2 (SGLT2) inhibition on renal function and albuminuria in patients with type 2 diabetes: a systematic review and meta-analysis.<h4>Aim</h4>To evaluate the effects of sodium-glucose co-transporter 2 (SGLT2) inhibition on renal function and albuminuria in patients with type 2 diabetes.<h4>Methods</h4>We conducted systematic searches of PubMed, Embase and Cochrane Central Register of Controlled Trials up to June 2016 and included randomized controlled trials of SGLT2 inhibitors in adult type 2 diabetic patients reporting estimated glomerular filtration rate (eGFR) and/or urine albumin/creatinine ratio (ACR) changes. Data were synthesized using the random-effects model.<h4>Results</h4>Forty-seven studies with 22,843 participants were included. SGLT2 inhibition was not associated with a significant change in eGFR in general (weighted mean difference (WMD), -0.33 ml/min per 1.73 m², 95% CI [-0.90 to 0.23]) or2017-01-01T00:00:00Z20172026-04-15T17:09:00.902Z2019-03-27T02:48:52ZS-EPMC54904612866393410.7717/peerj.3405