{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Asrress KN"],"funding":["British Heart Foundation"],"pagination":["24-34"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5491223"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["136(1)"],"pubmed_abstract":["<h4>Background</h4>The mechanisms governing exercise-induced angina and its alleviation by the most commonly used antianginal drug, nitroglycerin, are incompletely understood. The purpose of this study was to develop a method by which the effects of antianginal drugs could be evaluated invasively during physiological exercise to gain further understanding of the clinical impact of angina and nitroglycerin.<h4>Methods</h4>Forty patients (mean age, 65.2±7.6 years) with exertional angina and coronary artery disease underwent cardiac catheterization via radial access and performed incremental exercise using a supine cycle ergometer. As they developed limiting angina, sublingual nitroglycerin was administered to half the patients, and all patients continued to exercise for 2 minutes at the same"],"journal":["Circulation"],"pubmed_title":["Physiology of Angina and Its Alleviation With Nitroglycerin: Insights From Invasive Catheter Laboratory Measurements During Exercise."],"pmcid":["PMC5491223"],"funding_grant_id":["FS/11/90/29087","FS/11/43/28760","FS/14/11/30526","FS/13/15/30026","CS/16/3/32615","FS/12/15/29380","FS/10/62/28409"],"pubmed_authors":["Asrress KN","Clapp B","Chowienczyk PJ","Lockie T","Ellis H","De Silva K","Patterson T","Redwood SR","Ihsan S","Khawaja MZ","Marber MS","Perera D","Lumley M","Arri S","Guilcher A","Williams R","Plein S"],"additional_accession":[]},"is_claimable":false,"name":"Physiology of Angina and Its Alleviation With Nitroglycerin: Insights From Invasive Catheter Laboratory Measurements During Exercise.","description":"<h4>Background</h4>The mechanisms governing exercise-induced angina and its alleviation by the most commonly used antianginal drug, nitroglycerin, are incompletely understood. The purpose of this study was to develop a method by which the effects of antianginal drugs could be evaluated invasively during physiological exercise to gain further understanding of the clinical impact of angina and nitroglycerin.<h4>Methods</h4>Forty patients (mean age, 65.2±7.6 years) with exertional angina and coronary artery disease underwent cardiac catheterization via radial access and performed incremental exercise using a supine cycle ergometer. As they developed limiting angina, sublingual nitroglycerin was administered to half the patients, and all patients continued to exercise for 2 minutes at the same","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jul","modification":"2026-06-11T05:44:11.112Z","creation":"2026-06-11T03:08:41.96Z"},"accession":"S-EPMC5491223","cross_references":{"pubmed":["28468975"],"doi":["10.1161/CIRCULATIONAHA.116.025856"]}}