biostudies-literatureAsrress KNBritish Heart Foundation24-34https://www.ebi.ac.uk/biostudies/studies/S-EPMC5491223biostudies-literatureUnknown136(1)<h4>Background</h4>The mechanisms governing exercise-induced angina and its alleviation by the most commonly used antianginal drug, nitroglycerin, are incompletely understood. The purpose of this study was to develop a method by which the effects of antianginal drugs could be evaluated invasively during physiological exercise to gain further understanding of the clinical impact of angina and nitroglycerin.<h4>Methods</h4>Forty patients (mean age, 65.2±7.6 years) with exertional angina and coronary artery disease underwent cardiac catheterization via radial access and performed incremental exercise using a supine cycle ergometer. As they developed limiting angina, sublingual nitroglycerin was administered to half the patients, and all patients continued to exercise for 2 minutes at the sameCirculationPhysiology of Angina and Its Alleviation With Nitroglycerin: Insights From Invasive Catheter Laboratory Measurements During Exercise.PMC5491223FS/11/90/29087FS/11/43/28760FS/14/11/30526FS/13/15/30026CS/16/3/32615FS/12/15/29380FS/10/62/28409Asrress KNClapp BChowienczyk PJLockie TEllis HDe Silva KPatterson TRedwood SRIhsan SKhawaja MZMarber MSPerera DLumley MArri SGuilcher AWilliams RPlein SfalsePhysiology of Angina and Its Alleviation With Nitroglycerin: Insights From Invasive Catheter Laboratory Measurements During Exercise.<h4>Background</h4>The mechanisms governing exercise-induced angina and its alleviation by the most commonly used antianginal drug, nitroglycerin, are incompletely understood. The purpose of this study was to develop a method by which the effects of antianginal drugs could be evaluated invasively during physiological exercise to gain further understanding of the clinical impact of angina and nitroglycerin.<h4>Methods</h4>Forty patients (mean age, 65.2±7.6 years) with exertional angina and coronary artery disease underwent cardiac catheterization via radial access and performed incremental exercise using a supine cycle ergometer. As they developed limiting angina, sublingual nitroglycerin was administered to half the patients, and all patients continued to exercise for 2 minutes at the same2017-01-01T00:00:00Z2017 Jul2026-06-11T05:44:11.112Z2026-06-11T03:08:41.96ZS-EPMC54912232846897510.1161/CIRCULATIONAHA.116.025856