{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kovall RA"],"funding":["NCI NIH HHS"],"pagination":["228-241"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5492985"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41(3)"],"pubmed_abstract":["The Notch signaling pathway relies on a proteolytic cascade to release its transcriptionally active intracellular domain, on force to unfold a protective domain and permit proteolysis, on extracellular domain glycosylation to tune the forces exerted by endocytosed ligands, and on a motley crew of nuclear proteins, chromatin modifiers, ubiquitin ligases, and a few kinases to regulate activity and half-life. Herein we provide a review of recent molecular insights into how Notch signals are triggered and how cell shape affects these events, and we use the new insights to illuminate a few perplexing observations."],"journal":["Developmental cell"],"pubmed_title":["The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force."],"pmcid":["PMC5492985"],"funding_grant_id":["R01 CA178974"],"pubmed_authors":["Sprinzak D","Gebelein B","Kovall RA","Kopan R"],"additional_accession":[]},"is_claimable":false,"name":"The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force.","description":"The Notch signaling pathway relies on a proteolytic cascade to release its transcriptionally active intracellular domain, on force to unfold a protective domain and permit proteolysis, on extracellular domain glycosylation to tune the forces exerted by endocytosed ligands, and on a motley crew of nuclear proteins, chromatin modifiers, ubiquitin ligases, and a few kinases to regulate activity and half-life. Herein we provide a review of recent molecular insights into how Notch signals are triggered and how cell shape affects these events, and we use the new insights to illuminate a few perplexing observations.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 May","modification":"2024-11-11T19:54:09.538Z","creation":"2019-03-26T23:35:55Z"},"accession":"S-EPMC5492985","cross_references":{"pubmed":["28486129"],"doi":["10.1016/j.devcel.2017.04.001"]}}