biostudies-literatureWillmann JKNCI NIH HHS2133-2140https://www.ebi.ac.uk/biostudies/studies/S-EPMC5493049biostudies-literatureUnknown35(19)Purpose We performed a first-in-human clinical trial on ultrasound molecular imaging (USMI) in patients with breast and ovarian lesions using a clinical-grade contrast agent (kinase insert domain receptor [KDR] -targeted contrast microbubble [MB_KDR]) that is targeted at the KDR, one of the key regulators of neoangiogenesis in cancer. The aim of this study was to assess whether USMI using MB_KDR is safe and allows assessment of KDR expression using immunohistochemistry (IHC) as the gold standard. Methods Twenty-four women (age 48 to 79 years) with focal ovarian lesions and 21 women (age 34 to 66 years) with focal breast lesions were injected intravenously with MB_KDR (0.03 to 0.08 mL/kg of body weight), and USMI of the lesions was performed starting 5 minutes Journal of clinical oncology : official journal of the American Society of Clinical OncologyUltrasound Molecular Imaging With BR55 in Patients With Breast and Ovarian Lesions: First-in-Human Results.PMC5493049R01 CA155289U54 CA151459U54 CA119367U54 CA199075Martini MValluru KSLutz AMTesta ACWillmann JKBonomo LRindi GRinaldi PGambhir SSPetrone GfalseUltrasound Molecular Imaging With BR55 in Patients With Breast and Ovarian Lesions: First-in-Human Results.Purpose We performed a first-in-human clinical trial on ultrasound molecular imaging (USMI) in patients with breast and ovarian lesions using a clinical-grade contrast agent (kinase insert domain receptor [KDR] -targeted contrast microbubble [MB_KDR]) that is targeted at the KDR, one of the key regulators of neoangiogenesis in cancer. The aim of this study was to assess whether USMI using MB_KDR is safe and allows assessment of KDR expression using immunohistochemistry (IHC) as the gold standard. Methods Twenty-four women (age 48 to 79 years) with focal ovarian lesions and 21 women (age 34 to 66 years) with focal breast lesions were injected intravenously with MB_KDR (0.03 to 0.08 mL/kg of body weight), and USMI of the lesions was performed starting 5 minutes 2017-01-01T00:00:00Z2017 Jul2025-04-04T09:53:54.672Z2019-03-26T23:02:43ZS-EPMC54930492829139110.1200/JCO.2016.70.859410.1200/jco.2016.70.8594