biostudies-literaturePark HBNational Institute of Animal Science1061-1065https://www.ebi.ac.uk/biostudies/studies/S-EPMC5494477biostudies-literatureUnknown30(8)<h4>Objective</h4>This study was conducted to locate quantitative trait loci (QTL) influencing fatty acid (FA) composition in a large F₂ intercross between Landrace and Korean native pigs.<h4>Methods</h4>Eighteen FA composition traits were measured in more than 960 F₂ progeny. All experimental animals were genotyped with 165 microsatellite markers located throughout the pig autosomes.<h4>Results</h4>We detected 112 QTLs for the FA composition; Forty seven QTLs reached the genome-wide significant threshold. In particular, we identified a cluster of highly significant QTLs for FA composition on SSC12. QTL for polyunsaturated fatty acid on pig chromosome 12 (<i>F</i>-value = 97.2 under additive and dominance model, nominal p-value 3.6×10^-39) accounted for 16.9Asian-Australasian journal of animal sciencesGenome scan linkage analysis identifies a major quantitative trait loci for fatty acid composition in <i>longissimus dorsi</i> muscle in an F₂ intercross between Landrace and Korean native pigs.PMC5494477PJ01010502PJ01262701Park HBYoo CKLee JBCho ICBaek KSHan SHLim HTShin SMKim JHSon JKfalseGenome scan linkage analysis identifies a major quantitative trait loci for fatty acid composition in <i>longissimus dorsi</i> muscle in an F₂ intercross between Landrace and Korean native pigs.<h4>Objective</h4>This study was conducted to locate quantitative trait loci (QTL) influencing fatty acid (FA) composition in a large F₂ intercross between Landrace and Korean native pigs.<h4>Methods</h4>Eighteen FA composition traits were measured in more than 960 F₂ progeny. All experimental animals were genotyped with 165 microsatellite markers located throughout the pig autosomes.<h4>Results</h4>We detected 112 QTLs for the FA composition; Forty seven QTLs reached the genome-wide significant threshold. In particular, we identified a cluster of highly significant QTLs for FA composition on SSC12. QTL for polyunsaturated fatty acid on pig chromosome 12 (<i>F</i>-value = 97.2 under additive and dominance model, nominal p-value 3.6×10^-39) accounted for 16.92017-01-01T00:00:00Z2017 Aug2025-04-04T11:13:39.998Z2019-03-27T02:49:08ZS-EPMC54944772811144310.5713/ajas.16.0562