{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(1)"],"submitter":["Caputo F"],"pubmed_abstract":["Cerium oxide nanoparticles (CNPs) are novel synthetic antioxidant agents proposed for treating oxidative stress-related diseases. The synthesis of high-quality CNPs for biomedical applications remains a challenging task. A major concern for a safe use of CNPs as pharmacological agents is their tendency to agglomerate. Herein we present a simple direct precipitation approach, exploiting ethylene glycol as synthesis co-factor, to synthesize at room temperature nanocrystalline sub-10 nm CNPs, followed by a surface silanization approach to improve nanoparticle dispersibility in biological fluids. CNPs were characterized using transmission electron microscopy (TEM) observations, X-ray diffraction (XRD) analysis, thermogravimetric analysis (TGA), Fourier-transform infrared (FT-IR) spectroscopy, "],"journal":["Scientific reports"],"pagination":["4636"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5498533"],"repository":["biostudies-literature"],"pubmed_title":["A novel synthetic approach of cerium oxide nanoparticles with improved biomedical activity."],"pmcid":["PMC5498533"],"pubmed_authors":["Sienkiewicz A","Caputo F","Stellacci F","Traversa E","Ghibelli L","Mameli M","Licoccia S"],"additional_accession":[]},"is_claimable":false,"name":"A novel synthetic approach of cerium oxide nanoparticles with improved biomedical activity.","description":"Cerium oxide nanoparticles (CNPs) are novel synthetic antioxidant agents proposed for treating oxidative stress-related diseases. The synthesis of high-quality CNPs for biomedical applications remains a challenging task. A major concern for a safe use of CNPs as pharmacological agents is their tendency to agglomerate. Herein we present a simple direct precipitation approach, exploiting ethylene glycol as synthesis co-factor, to synthesize at room temperature nanocrystalline sub-10 nm CNPs, followed by a surface silanization approach to improve nanoparticle dispersibility in biological fluids. CNPs were characterized using transmission electron microscopy (TEM) observations, X-ray diffraction (XRD) analysis, thermogravimetric analysis (TGA), Fourier-transform infrared (FT-IR) spectroscopy, ","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jul","modification":"2025-04-18T20:30:53.121Z","creation":"2019-03-27T02:49:32Z"},"accession":"S-EPMC5498533","cross_references":{"pubmed":["28680107"],"doi":["10.1038/s41598-017-04098-6"]}}