{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Stefansson OA"],"funding":["Minningarsjodur Eggerts Briem","Gongum Saman","Icelandic Centre for Research (IS)"],"pagination":["469"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5498885"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["<h4>Background</h4>DNA repair of alkylation damage is defective in various cancers. This occurs through somatically acquired inactivation of the MGMT gene in various cancer types, including breast cancers. In addition to MGMT, the two E. coli AlkB homologs ALKBH2 and ALKBH3 have also been linked to direct reversal of alkylation damage. However, it is currently unknown whether ALKBH2 or ALKBH3 are found inactivated in cancer.<h4>Methods</h4>Methylome datasets (GSE52865, GSE20713, GSE69914), available through Omnibus, were used to determine whether ALKBH2 or ALKBH3 are found inactivated by CpG promoter methylation. TCGA dataset enabled us to then assess the impact of CpG promoter methylation on mRNA expression for both ALKBH2 and ALKBH3. DNA methylation analysis for the ALKBH3 promoter regio"],"journal":["BMC cancer"],"pubmed_title":["CpG promoter methylation of the ALKBH3 alkylation repair gene in breast cancer."],"pmcid":["PMC5498885"],"funding_grant_id":["152077-051","14193-051"],"pubmed_authors":["Jonasson JG","Gudjonsson T","Hermanowicz S","Tryggvadottir L","van der Horst J","Stefansson OA","Sigurdsson S","Hilmarsdottir H","Staszczak Z"],"additional_accession":[]},"is_claimable":false,"name":"CpG promoter methylation of the ALKBH3 alkylation repair gene in breast cancer.","description":"<h4>Background</h4>DNA repair of alkylation damage is defective in various cancers. This occurs through somatically acquired inactivation of the MGMT gene in various cancer types, including breast cancers. In addition to MGMT, the two E. coli AlkB homologs ALKBH2 and ALKBH3 have also been linked to direct reversal of alkylation damage. However, it is currently unknown whether ALKBH2 or ALKBH3 are found inactivated in cancer.<h4>Methods</h4>Methylome datasets (GSE52865, GSE20713, GSE69914), available through Omnibus, were used to determine whether ALKBH2 or ALKBH3 are found inactivated by CpG promoter methylation. TCGA dataset enabled us to then assess the impact of CpG promoter methylation on mRNA expression for both ALKBH2 and ALKBH3. DNA methylation analysis for the ALKBH3 promoter regio","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jul","modification":"2025-04-04T00:36:22.159Z","creation":"2019-03-27T02:49:33Z"},"accession":"S-EPMC5498885","cross_references":{"pubmed":["28679371"],"doi":["10.1186/s12885-017-3453-8"]}}