biostudies-literatureBelsky DWEconomic and Social Research CouncilNICHD NIH HHSNIA NIH HHSJacobs FoundationMedical Research CouncilMinistry of Business, Innovation and EmploymentNational Institute on Aging644-651https://www.ebi.ac.uk/biostudies/studies/S-EPMC5506399biostudies-literatureUnknown16(4)Therapies to extend healthspan are poised to move from laboratory animal models to human clinical trials. Translation from mouse to human will entail challenges, among them the multifactorial heterogeneity of human aging. To inform clinical trials about this heterogeneity, we report how humans' pace of biological aging relates to personal-history characteristics. Because geroprotective therapies must be delivered by midlife to prevent age-related disease onset, we studied young-adult members of the Dunedin Study 1972-73 birth cohort (n = 954). Cohort members' Pace of Aging was measured as coordinated decline in the integrity of multiple organ systems, by quantifying rate of decline across repeated measurements of 18 biomarkers assayed when cohort members were ages 26, 32, and 38 years. TheAging cellImpact of early personal-history characteristics on the Pace of Aging: implications for clinical trials of therapies to slow aging and extend healthspan.PMC5506399P30AG028716P30 AG034424R01AG032282R01 AG032282ES/M010309/11R01AG049789MR/P005918/1P30 AG028716P2C HD065563R01 AG048895P30AG034424R01 AG049789R01AG048895Cohen HJMoffitt TEKraus WEBelsky DWCaspi ARamrakha SPoulton RfalseImpact of early personal-history characteristics on the Pace of Aging: implications for clinical trials of therapies to slow aging and extend healthspan.Therapies to extend healthspan are poised to move from laboratory animal models to human clinical trials. Translation from mouse to human will entail challenges, among them the multifactorial heterogeneity of human aging. To inform clinical trials about this heterogeneity, we report how humans' pace of biological aging relates to personal-history characteristics. Because geroprotective therapies must be delivered by midlife to prevent age-related disease onset, we studied young-adult members of the Dunedin Study 1972-73 birth cohort (n = 954). Cohort members' Pace of Aging was measured as coordinated decline in the integrity of multiple organ systems, by quantifying rate of decline across repeated measurements of 18 biomarkers assayed when cohort members were ages 26, 32, and 38 years. The2017-01-01T00:00:00Z2017 Aug2025-04-18T14:56:31.946Z2019-03-27T02:50:06ZS-EPMC55063992840173110.1111/acel.12591