{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Morisset J"],"funding":["National Center for Advancing Translational Sciences","NCATS NIH HHS","Nina Ireland Program for Lung Health"],"pagination":["51-56"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5506836"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["127"],"pubmed_abstract":["Background
Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is associated with significant morbidity and mortality. Similarities have been observed between patients with idiopathic pulmonary fibrosis (IPF) and the UIP (usual interstitial pneumonia) form of RA-ILD. The GAP (gender, age, physiology) model has been shown to predict mortality in patients with IPF, but its ability to predict mortality in RA-ILD is not known.Methods
We identified 309 patients with RA-ILD at 4 academic centers with ongoing longitudinal cohorts of patients with ILD. The primary endpoint was mortality. To handle missing data (n = 219 subjects with complete dataset), multiple imputation by iterative chained equations was used. Using the GAP model as a baseline, we assessed improveme"],"journal":["Respiratory medicine"],"pubmed_title":["The performance of the GAP model in patients with rheumatoid arthritis associated interstitial lung disease."],"pmcid":["PMC5506836"],"funding_grant_id":["KL2 TR000143","UCSF-CTI KL2TR000143"],"pubmed_authors":["Jones KD","Lee BY","Hu X","King TE","Gross AJ","Morisset J","Tonelli R","Cerri S","Manfredi A","Lee JS","Kim DS","Vittinghoff E","Elicker BM","Ryu JH","Ley B","Wolters PJ","Collard HR","Sebastiani M"],"additional_accession":[]},"is_claimable":false,"name":"The performance of the GAP model in patients with rheumatoid arthritis associated interstitial lung disease.","description":"Background
Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is associated with significant morbidity and mortality. Similarities have been observed between patients with idiopathic pulmonary fibrosis (IPF) and the UIP (usual interstitial pneumonia) form of RA-ILD. The GAP (gender, age, physiology) model has been shown to predict mortality in patients with IPF, but its ability to predict mortality in RA-ILD is not known.Methods
We identified 309 patients with RA-ILD at 4 academic centers with ongoing longitudinal cohorts of patients with ILD. The primary endpoint was mortality. To handle missing data (n = 219 subjects with complete dataset), multiple imputation by iterative chained equations was used. Using the GAP model as a baseline, we assessed improveme","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jun","modification":"2025-04-04T19:28:28.991Z","creation":"2019-03-26T23:38:52Z"},"accession":"S-EPMC5506836","cross_references":{"pubmed":["28502419"],"doi":["10.1016/j.rmed.2017.04.012"]}}