{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3(7)"],"submitter":["Gaudry MJ"],"pubmed_abstract":["Mitochondrial uncoupling protein 1 (UCP1) is essential for nonshivering thermogenesis in brown adipose tissue and is widely accepted to have played a key thermoregulatory role in small-bodied and neonatal placental mammals that enabled the exploitation of cold environments. We map <i>ucp1</i> sequences from 133 mammals onto a species tree constructed from a ~51-kb sequence alignment and show that inactivating mutations have occurred in at least 8 of the 18 traditional placental orders, thereby challenging the physiological importance of UCP1 across Placentalia. Selection and timetree analyses further reveal that <i>ucp1</i> inactivations temporally correspond with strong secondary reductions in metabolic intensity in xenarthrans and pangolins, or in six other lineages coincided with a ~30 "],"journal":["Science advances"],"pagination":["e1602878"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5507634"],"repository":["biostudies-literature"],"pubmed_title":["Inactivation of thermogenic UCP1 as a historical contingency in multiple placental mammal clades."],"pmcid":["PMC5507634"],"pubmed_authors":["Jastroch M","Treberg JR","Gaudry MJ","Signore AV","Starrett J","Campbell KL","Wales N","Paijmans JLA","Springer MS","Hofreiter M"],"additional_accession":[]},"is_claimable":false,"name":"Inactivation of thermogenic UCP1 as a historical contingency in multiple placental mammal clades.","description":"Mitochondrial uncoupling protein 1 (UCP1) is essential for nonshivering thermogenesis in brown adipose tissue and is widely accepted to have played a key thermoregulatory role in small-bodied and neonatal placental mammals that enabled the exploitation of cold environments. We map <i>ucp1</i> sequences from 133 mammals onto a species tree constructed from a ~51-kb sequence alignment and show that inactivating mutations have occurred in at least 8 of the 18 traditional placental orders, thereby challenging the physiological importance of UCP1 across Placentalia. Selection and timetree analyses further reveal that <i>ucp1</i> inactivations temporally correspond with strong secondary reductions in metabolic intensity in xenarthrans and pangolins, or in six other lineages coincided with a ~30 ","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jul","modification":"2026-05-05T11:14:34.572Z","creation":"2019-03-26T23:25:50Z"},"accession":"S-EPMC5507634","cross_references":{"pubmed":["28706989"],"doi":["10.1126/sciadv.1602878"]}}